Lack of hepatitis C virus reinfection in lifetime of Japanese general population with previous hepatitis C virus (HCV) infection successfully treated with anti-HCV therapy |
| |
| Affiliation: | 1. Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan;2. Department of Nursing, Gifu Kyoritsu University, Ogaki, Japan;3. Department of Epidemiology, Infectious Disease Control, and Prevention, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima, Japan;1. Department of Social Medicine, National Center for Child Health and Development, Tokyo, Japan;2. Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, (UCLA), Los Angeles, CA, USA;3. Department of Pediatrics, UCLA Mattel Children''s Hospital, University of California, Los Angeles, (UCLA), Los Angeles, CA, USA;4. Division of Infectious Diseases, Department of Pediatrics, Tokyo Metropolitan Children''s Medical Center, Tokyo, Japan;5. Department of Infectious Diseases, National Center for Global Health and Medicine, Tokyo, Japan;6. Division of Infectious Diseases, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan;7. Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, USA;1. Department of Surgery, Japan Community Health Care Organization Sagamino Hospital, Sagamihara, Japan;2. First Department of Surgery, Dokkyo Medical University, Shimotsuga, Japan |
| |
| Abstract: | IntroductionAchieving sustained virologic response (SVR) to antiviral therapy for hepatitis C virus (HCV) infection is an important step for eliminating HCV infection worldwide. However, recurrence of HCV viremia may occur due to HCV reinfection and confirmation of the long-term absence of HCV viremia, i.e., the absence of HCV reinfection, is necessary in post-SVR patients. In this report, we studied the long-term results of serum HCV RNA measurements in patients with SVR in whom serum HCV RNA was monitored over decades.MethodsSerum HCV RNA was measured at every visit in a total of 1,392 SVR patients who underwent regular visits to the hospital after SVR, of whom 434 patients (31.2%) had continued regular visits for more than 10 years.ResultsNo patients demonstrated positive serum HCV RNA during follow-up after SVR with a total of 23,187 HCV RNA tests.ConclusionsThis study confirmed the absence of reinfection with HCV in Japanese general population with SVR for decades. Once HCV had been eradicated by anti-HCV therapy, HCV infection rarely recurs even in a lifetime in Japan, unless patients are in high risk group of HCV infection and drop out for follow-up. |
| |
| Keywords: | Hepatitis C virus Sustained virologic response Recurrence Reinfection |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
