Intranasal Administration of Retinyl Palmitate with a Respiratory Virus Vaccine Corrects Impaired Mucosal IgA Response in the Vitamin A-Deficient Host |
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| Authors: | Sherri L. Surman Bart G. Jones Rajeev Rudraraju Robert E. Sealy Julia L. Hurwitz |
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| Affiliation: | aDepartment of Infectious Diseases, St. Jude Children''s Research Hospital, Memphis, Tennessee, USA;bDepartment of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, USA |
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| Abstract: | Our previous studies showed that intranasal vaccination of vitamin A-deficient (VAD) mice failed to induce normal levels of upper respiratory tract IgA, a first line of defense against respiratory virus infection. Here we demonstrate that the impaired responses in VAD animals are corrected by a single intranasal application of retinyl palmitate with the vaccine. Results encourage the clinical testing of intranasal vitamin A supplements to improve protection against respiratory viral disease in VAD populations. |
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