Disturbed Left Atrial Function is Associated with Paroxysmal Atrial
Fibrillation in Hypertension |
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Authors: | Erhan Tenekecioglu Fahriye Vatansever Agca Ozlem Arican Ozluk Kemal Karaagac Serafettin Demir Tezcan Peker Mustafa Kuzeytemiz Muhammed Senturk Mustafa Y?lmaz |
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Institution: | 1. Department of Cardiology - Bursa Yuksek Ihtisas Education and Resarch Hospital, Bursa, Turkey ;2. Department of Cardiology, Adana State Hospital, Adana, Turkey |
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Abstract: | BackgroundHypertension is the most prevalent and modifiable risk factor for atrial
fibrillation. The pressure overload in the left atrium induces pathophysiological
changes leading to alterations in contractile function and electrical properties.
ObjectiveIn this study our aim was to assess left atrial function in hypertensive patients
to determine the association between left atrial function with paroxysmal atrial
fibrillation (PAF). MethodWe studied 57 hypertensive patients (age: 53±4 years; left ventricular ejection
fraction: 76±6.7%), including 30 consecutive patients with PAF and 30 age-matched
control subjects. Left atrial (LA) volumes were measured using the modified
Simpson''s biplane method. Three types of LA volume were determined: maximal
LA(LAVmax), preatrial contraction LA(LAVpreA) and minimal LA volume(LAVmin). LA
emptying functions were calculated. LA total emptying volume = LAVmax−LAVmin and
the LA total EF = (LAVmax-LAVmin )/LAVmax, LA passive emptying volume = LAVmax−
LAVpreA and the LA passive EF = (LAVmax-LAVpreA)/LAVmax, LA active emptying volume
= LAVpreA−LAVmin and LA active EF = (LAVpreA-LAVmin )/LAVpreA. ResultsThe hypertensive period is longer in hypertensive group with PAF. LAVmax
significantly increased in hypertensive group with PAF when compared to
hypertensive group without PAF (p=0.010). LAAEF was significantly decreased in
hypertensive group with PAF as compared to hypertensive group without PAF
(p=0.020). A'' was decreased in the hypertensive group with PAF when compared to
those without PAF (p = 0.044).ConclusionIncreased LA volume and impaired LA active emptying function was associated with
PAF in untreated hypertensive patients. Longer hypertensive period is associated
with PAF. |
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Keywords: | Hypertension Atrial function left Atrial fibrillation / physiopathology |
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