Maternal exposure to smoking and infant's wheeze and asthma: Japan Environment and Children's Study |
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| Affiliation: | 4. Principal Investigator, Nagoya City University, Nagoya, Japan;5. National Institute for Environmental Studies, Tsukuba, Japan;6. National Center for Child Health and Development, Tokyo, Japan;7. Hokkaido University, Sapporo, Japan;8. Tohoku University, Sendai, Japan;9. Fukushima Medical University, Fukushima, Japan;10. Chiba University, Chiba, Japan;11. Yokohama City University, Yokohama, Japan;12. University of Yamanashi, Chuo, Japan;13. University of Toyama, Toyama, Japan;14. Kyoto University, Kyoto, Japan;15. Osaka University, Suita, Japan;p. Hyogo College of Medicine, Nishinomiya, Japan;q. Tottori University, Yonago, Japan;r. Kochi University, Nankoku, Japan;s. University of Occupational and Environmental Health, Kitakyushu, Japan;t. Kumamoto University, Kumamoto, Japan;1. Department of Pediatrics, Faculty of Medicine, University of Toyama, Toyama, Japan;2. Department of Public Health, Faculty of Medicine, University of Toyama, Toyama, Japan;3. Toyama Regional Center for Japan Environment and Children''s Study (JECS), University of Toyama, Toyama, Japan |
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| Abstract: | BackgroundEvidence regarding independent effects of maternal smoking in different time frames of pregnancy and maternal exposure to secondhand smoke on the development of wheeze/asthma in her offspring is limited. We aimed to investigate the effect of maternal exposure to tobacco smoke on wheeze/asthma development at 1 year of age in her offspring using data from the nationwide birth cohort study in Japan.MethodsPregnant women who lived in the 15 designated regional centers throughout Japan were recruited. We obtained information about maternal smoking or secondhand smoke status and wheeze/asthma development in the offspring from a self-administered questionnaire.ResultsWe analyzed 90,210 singleton births. Current maternal smoking during pregnancy increased the risks of wheeze/asthma in the offspring compared with no maternal smoking (wheeze: 1–10 cigarettes/day: adjusted odds ratio (aOR) 1.436, 95% CI 1.270–1.624; ≧11 cigarettes/day: aOR 1.669, 95% CI 1.341–2.078; asthma: 1–10 cigarettes/day: aOR 1.389, 95% CI 1.087–1.774; ≧11 cigarettes/day: aOR 1.565, 95% CI 1.045–2.344). Daily maternal exposure to secondhand smoke during pregnancy also increased the risks of wheeze/asthma in her offspring compared with no secondhand smoke exposure (wheeze: aOR 1.166, 95% CI 1.083–1.256; asthma: aOR 1.258, 95% CI 1.075–1.473). The combination of current maternal smoking during pregnancy and maternal history of allergy increased the risks of wheeze/asthma in her offspring (wheeze: aOR 2.007, 95% CI 1.739–2.317; asthma: aOR 1.995, 95% CI 1.528–2.605).ConclusionsWe found that current maternal smoking and maternal secondhand smoke exposure during pregnancy increased the risks of wheeze and asthma in her offspring. |
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| Keywords: | Asthma Cohort study Mother Offspring Tobacco smoke aOR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0040" }," $$" :[{" #name" :" text" ," _" :" adjusted odds ratio JECS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0050" }," $$" :[{" #name" :" text" ," _" :" Japan Environment and Children's Study SHS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0060" }," $$" :[{" #name" :" text" ," _" :" secondhand smoke |
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