Metabolic and behavioral effects of olanzapine and fluoxetine on the model organism Caenorhabditis elegans |
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Authors: | Abdullah Almotayri Jency Thomas Mihiri Munasinghe Maneka Weerasinghe Deniz Heydarian Markandeya Jois |
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Affiliation: | 1. Department of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Bundoora, Victoria, Australia;2. Al Baha University, Department of Biology, Al Baha, Saudi Arabia |
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Abstract: | The use of many psychotropic drugs (PDs) is associated with increased caloric intake, significant weight gain, and metabolic disorders. The nematode Caenorhabditis elegans (C. elegans) has been used to study the effects of PDs on food intake. However, little is known about PDs effects on the body fat of C. elegans. In C. elegans, feeding behavior and fat metabolism are regulated through independent mechanisms. This study aims to evaluate the body fat and food intake of C. elegans in response to treatment olanzapine and fluoxetine. Here we report that, with careful consideration to the dosage used, administration of fluoxetine and olanzapine increases body fat and food intake in C. elegans. |
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Keywords: | C. elegans Obesity Olanzapine Fluoxetine Body fat Food intake |
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