A comparative immunohistochemical analysis of cortactin in orthokeratinized odontogenic cyst (OOC), sporadic odontogenic keratocyst (OKC), and syndromic OKC |
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| Affiliation: | 1. Department of Oral Pathology and Microbiology, Nair Hospital Dental College, Dr. A.L Nair Road, Mumbai Central, Mumbai, 400008, India;2. Furness General Hospital-Morecambe Bay Hospital Trust, Dalton Lane, Barrow in Furness, Cumbria, United Kingdom;1. Department of Periodontology, Faculty of Dentistry, Hacettepe University, Ankara, Turkey;2. Department of Physics Engineering, Hacettepe University, Ankara, Turkey;3. Department of Anatomy, Hacettepe University Faculty of Medicine, Ankara, Turkey;4. Department of Biostatistics, Faculty of Medicine, Hacettepe University, Ankara, Turkey;5. Department of Prosthodontics, Faculty of Dentistry, Hacettepe University, Ankara, Turkey;1. Department of Anatomy, Tokyo Dental College, 2-9-18 Kanda-misakicho, Tokyo, 101-0061, Japan;2. Tokyo Dental College Research Branding Project, 2-9-18 Kanda-misakicho, Tokyo, 101-0061, Japan;3. Department of Fixed Prosthodontics, 2-9-18 Kanda-misakicho, Tokyo, 101-0061, Japan;4. Department of Oral Health and Clinical Science, Division of Dysphagia Rehabilitation, 2-9-18 Kanda-misakicho, Tokyo, 101-0061, Japan;5. Laboratory of Biology, 2-9-18 Kanda-misakicho, Tokyo, 101-0061, Japan;1. Department of Zoology, Guru Ghasidas Vishwavidyalaya, Bilaspur, India;2. Department of Biochemistry, Late Atal Bihari Vajpayee Memorial Medical College Rajnandgaon (C.G.), India;3. Department of Public Health, Nellore Municipal Corporation, Nellore, India;4. Department of Immunopathology, Institute of Lungs Biology and Disease, Comprehensive Pneumology Center, Helmholtz Zentrum, Neuherberg, Munich, 85764, Germany;1. School of Health Sciences, Positivo University, 5300 Professor Pedro Viriato Parigot de Souza Street, Curitiba, 81280-330, PR, Brazil;2. Department of Periodontics and Oral Hygiene, School of Dentistry, The University of Texas Health Science Center at Houston, 7500 Cambridge St, Houston, 77054, TX, USA;3. Department of Medical Anatomical Sciences, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, 615 E 3rd St Pomona, 91766, CA, USA;4. Master Graduation on Urban and Industrial Environments, Polytechnic Center, Federal University of Paraná, 100 Cel. Francisco H. dos Santos Avenue, Curitiba, 81530-000, PR, Brazil;5. Department of Periodontics, IOA Boutique Curitiba, 6823 Sete de Setembro Avenue, Curitiba, 80240-001, PR, Brazil;6. Department of Stomatology, School of Dentistry, Federal University of Parana, 632 Prefeito Lothario Meissner Avenue, Curitiba, 80210-170, PR, Brazil;1. Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, 230-8501, Japan;2. Department of Periodontology, Tsurumi University School of Dental Medicine, Yokohama, 230-8501, Japan;3. Department of Oral Anatomy, Tsurumi University School of Dental Medicine, Yokohama, 230-8501, Japan;4. Department of Orthodontics, Tsurumi University School of Dental Medicine, Yokohama, 230-8501, Japan;5. Department of Dental Anesthesiology, Tsurumi University School of Dental Medicine, Yokohama, 230-8501, Japan;6. Department of Pediatric Dentistry, Tsurumi University School of Dental Medicine, Yokohama, 236-8501, Japan |
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| Abstract: | ObjectivesTo evaluate and compare the immunohistochemical expression of cortactin in the epithelial lining of orthokeratinized odontogenic cyst (OOC), sporadic odontogenic keratocyst (OKC), and syndromic OKC.MethodsFormalin-fixed paraffin-embedded tissue blocks of histopathologically diagnosed cases of OOC, OKC, syndromic OKC, normal buccal mucosa (NBM), and oral squamous cell carcinoma (OSCC) were examined for immunohistochemical expression of cortactin. Clear brown cytoplasmic and membranous staining was considered positive.ResultsA statistically significant difference was observed between OOC and syndromic OKC (p < 0.001), as well as between sporadic OKC and syndromic OKC (p < 0.001). Although not statistically significant, the expression of cortactin was slightly higher in the basal layer of NBM (mean = 0.47), OOC (mean = 0.27), sporadic OKC (mean = 0.47) syndromic OKC (mean = 1.53), and OSCC (mean = 0.67) than in the parabasal layers of NBM (mean = 0.27), OOC (mean = 0.20), sporadic OKC (mean = 0.47), syndromic OKC (mean = 1.27), and OSCC (mean = 0.60).ConclusionThe expression of cortactin in the basal layer may suggest the formation of invadopodia in the basal layer where the invasion mechanism occurs. This finding is further supported by the higher localization of cortactin in areas of epithelial budding and daughter cysts in syndromic OKC, thereby reaffirming its possible association with recurrence. |
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| Keywords: | Cortactin Odontogenic Keratocyst Invasion Recurrence Syndromic OKC |
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