全肺切除术对非小细胞肺癌患者术后肺功能及生活质量影响的临床研究

目的研究非小细胞肺癌(non-small cell lung cancer,NSCLC)患者全肺切除术后的长期生活质量。方法采用生活质量测定量表核心量表(QLQ-C30)调查从2008年1月至2010年12月在我科治疗的60例全肺切除术后NSCLC患者,将其分为两组,A组:年龄<60岁的患者;B组:年龄≥60岁的患者。对其术前和术后3、6和12个月的QLQ-C30得分进行比较。结果术前、术后生活质量相比较:①功能方面:两组术后体力均显著下降,但两组间比较无统计学差异;②症状方面:两组术后第3、6个月疲乏、呼吸困难均加重,B组患者术后第12个月呼吸困难与术前比较仍有统计学差异(P<0.05);B组患者疼痛、呼吸困难症状,在术后3、6个月较A组明显增加,差异有统计学意义(P<0.05);B组患者疲乏症状,在术后3、6、12个月较A组明显增加,差异有统计学意义(P<0.05);其余症状指标评分均无统计学差异。结论年龄<60岁的NSCLC患者行全肺切除术后的生活质量优于年龄≥60岁的患者。

A Clinical Study of Long-term Quality of the Patients'Life after Pneumonectomy for NSCLC

Objective To investigate the long-term quality of the patients＇life after pneumonectomy for NSCLC. Methods The quality of life questionnaire, EORTC QLQ-C30 Chinese version, was used to assess the patients quality of life. All the 60 patients from January 2008 to December 2010 in our department treated for NSCLC were collected in this study, and were divided into two groups, group A, 〈 60 years old and group B, ≥60 years old. The QLQ-C30 scores of preoperative and postoperative 3, 6 and 12 months were compared each other. Results To compare the preoperative and postoperative quality of life between the two groups, the postoperative physical function significantly declined in the aspect of physical strength in each group, but there was no statistical difference between the two groups. In the aspect of symptoms, fatigue and dyspnea were aggravated 3 and 6 months after operation in both groups. And the dyspnea was still obvious 12 months after op- eration in group B. Comparing with the group A, pain and dyspnea was more serious in group B 3 and 6 months after operation; While fatigue was more aggravated in group B 3, 6 and 12 months after operation. The rest of the symptom index scores had no statistical difference. Conclusion It is better of the life quality for the 〈 60 years old NSCLC patients underwent radical pneumonectomy.