呼吸导航3D-SSFP序列评价冠状动脉粥样硬化斑块的强化

目的通过非对比增强及对比增强呼吸导航三维稳态自由进动(3D-SSFP)序列评价冠状动脉粥样硬化斑块的强化。资料与方法选取19例多层螺旋CT(MDCT)显示的位于冠状动脉近、中段的非钙化或以非钙化为主的混合性斑块为研究对象,采用呼吸导航3D-SSFP序列对斑块所在的血管进行成像。采用多平面重组(MPR)方法重组出冠状动脉粥样硬化斑块的横轴位影像用来评价斑块。增强前后斑块与周围结缔组织的对比噪声比(CNR)增加50%以上定义为斑块有强化。结果14例患者磁共振血管成像(MRA)上斑块显示清晰,共24个斑块,其中强化11个。强化斑块中有5个于增强后5min发生强化,余6个于增强后10～15min发生强化。13个未强化斑块中有4个平扫呈高信号,9个呈低信号。增强前后24个斑块与周围结缔组织的CNR分别为10.29±4.28和14.08±5.8,两者之间差异有统计学意义(P<0.05)。结论对比增强MRA可以显示冠状动脉粥样硬化斑块的强化,预示斑块的不稳定性。

The Evaluation of Navigator Gated 3D-SSFP Sequence in Coronary Atherosclerotic Plaque Enhancement

Objective To evaluate the enhancement of coronary atherosclerotic plaque revealed by CTA using pre-and post-contrast navigator-gated 3D-SSFP sequence.Materials and Methods 19 patients with non-calcified or mixed plaques with main non-calcified component on the proximal or middle segments of coronary artery detected by MDCT were recruited for MRA study. The coronary MRA was performed using a navigator-gated 3D-SSFP sequence before and after administration of Gd-DTPA. Coronary MRA was acquired 2-3 times after...