Abstract: | In acute experiments on Nembutal-anesthetized cats, the effect of opiate receptor agonists DAGO, DSLET, and dinorphin A1–13 on the incidence of idioventricular rhythm disturbances, including ventricular tachycardia and fibrillation, was studied
under conditions of occlusion of circumflex branch of the left coronary artery and stimulation of the sensorimotor cortex.
The most pronounced effects were observed with DSLET and dinorphin A1–13. These preparations completely prevented ventricular fibrillation. DAGO produced a less pronounced protective effect probably
because of parallel increase in plasma catecholamine concentration.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 5, pp. 504–506, May, 2000 |