碳酸氢钠雾化吸入治疗支气管哮喘的疗效观察

目的观察碳酸氢钠雾化吸入在儿童支气管哮喘治疗中的作用。方法支气管哮喘急性发作患儿128例，随机分为观察组和对照组。对照组给予常规抗感染和激素、支气管扩张剂雾化吸入治疗，观察组在对照组基础上加用碳酸氢钠雾化吸入治疗。观察患儿治疗前后治疗效果以及外周血白细胞介素－6（IL-6）、白细胞介素-8（IL-8）和肿瘤坏死因子－α（TNF－α）等的水平的变化。结果观察组显效率（59．4％）和总有效率（95．3％）均优于对照组（40．6％，82．8％），差异均有统计学意义（均P〈0．05）。观察组患儿症状和体征消失时间以及平均住院时间均显著短于对照组。两组患儿治疗后IL-6、IL－8和TNF－α等的水平均较治疗前显著降低，观察组降低更为显著，差异均有统计学意义（均P〈0．05）。结论碳酸氢钠雾化吸入治疗支气管哮喘可显著改善患儿症状和体征、缩短病程，并降低炎性因子的水平。

The curative effects of jet nebulization with sodium bicarbonate on the patients withbronchial asthma

Objective To observe the effects of jet nebulization with sodium bicarbonate on the children with bronchial asthma.Methods 128 children with bronchial asthma were collected and randomly divided into observation group and control group. Conventional treatment by anti-infection and jet nebulization with hormone and bronchodilators were used in control group. Jet nebulization with sodium bicarbonate combination with conventional treatment was used in observation group. The therapeutic efficacy, clinical symptom, physical sign, the stay time, the occurrence of adverse reaction and the levels of IL-6, IL-8 and TNF-α in peripheral blood were observed. Results There were no severity adverse reactions happened in the two groups. The excellence rate was 59.4％ and total effective rate was 95. 3％ in observation group which were significantly higher that in control group( P ＜ 0. 05 ). The extinction time of clinical symptom and physical sign were significantly shorter than that in control group. The levels of IL-6, IL-8 and TNF-α in peripheral blood decreased notably after therapy than before treatment in the two groups. The decreased changes in observation group were significant than that in control group ( P ＜ 0. 05 ). Conclusion Jet nebulization with sodium bicarbonate could improve the clinical symptom and physical sign and shorten the course of disease of children with bronchial asthma. It also could decrease the secrete of inflammatory factor and get satisfactory curative effect.