联合检测CA19-9、CEA、AFP和Fer对消化道恶性肿瘤的诊断价值

目的探讨联合检测血清糖类抗原19-9（CA19-9）、癌胚抗原（CEA）、甲胎蛋白（AFP）和铁蛋白（Fer）对消化道恶性肿瘤的临床诊断价值。方法用电化学发光法检测恶性消化道肿瘤183例和良性消化道疾病患者及健康体检者各40例血清肿瘤标志物的含量。结果在消化道恶性肿瘤患者和消化道良性疾病患者血清各肿瘤标志物水平均有上升，而四项联合检测的检出率较单一肿瘤标志物在消化道恶性肿瘤中有显著升高。结论联合检测血清CAl9-9、CEA、AFP和Fer水平，能显著提高对消化道肿瘤诊断的灵敏度。

Clinical value of combined detection of CA 1 9 - 9, CEA, AFP and Fer in diagnosis of digestive system neoplasm

Objective To explore the clinical value of combined detection of serum carbohydrate antigen 19-9(CA19-9) ,carcinoembryonic antigen( CEA), alpha-fetoprotein(AFP) and ferritin(Fer) in the diagnosis of digestive system neoplasm. Methods 183 cases of digestive system neoplasm and 40 patients with benign digestive diseases and 40 healthy contrll were selected. The serum tumor marker levels were detected by electrochemiluminescence assay. Results In digestive system neoplasm patients and patients with benign digestive disease, the level of the tumor markers were increased,while the detection rate of four joint detection test than a single tumor marker in digestive system neoplasm were significantly increased. Conclusion Combined detection of serum CA19-9, CEA, AFP, and Fer level, could significantly improve the sensitivity of diagnosis of digestive tract tumors.