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多重耐药肺炎克雷伯菌的分析
引用本文:郑宇琼,陈淑贞,蔡应木,林少微.多重耐药肺炎克雷伯菌的分析[J].中国基层医药,2008,15(11).
作者姓名:郑宇琼  陈淑贞  蔡应木  林少微
作者单位:汕头大学医学院第一附属医院检验科,广东省汕头,515041
摘    要:目的 了解某地区多重耐药肺炎克雷伯茵的特点,为临床治疗及控制医院感染提供理论依据.方法 用K-B法进行常规药敏试验,筛选出多重耐药肺炎克雷伯菌,用确认试验检测超广谱B-内酰胺酶(ES-BLs),同时以头孢西丁三相试验检测以上菌株产AmpC酶情况.结果 107株多重耐药肺炎克雷伯菌中单一检出产ESBLs 53株(49.5%),产AmpC酶30株(28.0%),同时产ESBLs和AmpC酶24株(22.4%).它们对氨基苷类、喹诺酮类及头孢菌素类药物表现出较高的耐药性.结论 某地区多重耐药肺炎克雷伯菌产酶率较高,主要产ESBLs和AmpC酶,应加强其耐药性监测,合理选用抗生素,减缓多重耐药菌株的产生.

关 键 词:克雷伯菌  肺炎  多重耐药  AmpC酶

Analysis of the multi-resistance to antibiotics of clinical isolated klebsiella pneumoniae
ZHENG Yu-qiong,CHEN Shu-zhen,CAI Ying-mu,LIN Shao-wei.Analysis of the multi-resistance to antibiotics of clinical isolated klebsiella pneumoniae[J].Chinese Journal of Primary Medicine and Pharmacy,2008,15(11).
Authors:ZHENG Yu-qiong  CHEN Shu-zhen  CAI Ying-mu  LIN Shao-wei
Abstract:Objective To investigate the multi-resistance to antibiotics of clinical isolated klebsiella pneumoniae.Methods The resistance to antibiotics of clinical isolated klebsiella pneumoniae were monitored.The discconfirmatory test was used to detect extended-spectrum β-lactamases(ESBLs) and cefoxitin three-dimension was used to detect AmpC β-lactamases.Results Among the isolates there were 53 strains of ESBLs-producing bacteria (49.5% ), 30 strains of AmpC-producing bacteria(28.0%), 24 strains of ESBLs + AmpC-producing bacteria (22.46%).They were high resistance to aminoglycosides,quinolones and cephalosporins.Conclusion The multi-resistance to antibiotics of clinical isolated klebsiella pneumoniae were widespread.It is important to control nosocomial infection to strengthen the detection of the epidemiology of ESBLs and AmpC β-lactamases in clinical isolates.
Keywords:ESBLs
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