| 纳米级二氧化硅N-1、N-2抗疱疹病毒2型效果的实验观察 |
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| 引用本文： | 陈国良,李晓山,单菁萱,盛晓蓉. 纳米级二氧化硅N-1、N-2抗疱疹病毒2型效果的实验观察[J]. 安徽医学, 2002, 23(6): 5-6. DOI: 10.3969/j.issn.1000-0399.2002.06.002 |
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| 作者姓名： | 陈国良 李晓山 单菁萱 盛晓蓉 |
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| 作者单位： | 230061,合肥,安徽省医学科学研究所 |
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| 摘 要： | 目的观察二氧化硅(SiO2)N-1、N-2抗疱疹病毒2型(HSV-2)作用.方法根据实验病毒感染细胞致病和药物特性,先测定HSV-2的毒力,测算出病毒对细胞的半数感染量(TCID50).再测定药物对细胞毒性,找出药物最大无毒浓度TCDo,最后测定药物SiO2 N-1、N-2对病变细胞(CPE)作用的半数有效剂量.结果SiO2 N-1、N-2对病变细胞(CPE)作用的半数有效剂量,SiO2 N-1 IC50为1/3200,SiO2N-2 IC50为Cm/4即1/8.结论SiO2(N-1、N-2)具有一定的抗疱疹病毒(HSV-2)作用.
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| 关 键 词： | 二氧化硅 疱疹病毒-2型(HSV-2) |
| 修稿时间： | 2002-07-08 |
Anti - herpessimplexvirus 2 effect of nanometer class silicon dioxide |
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| Chen Guoliang,Li Xiaoshang,Shan Jingxuan,et al Anhui Institute of Medical Sciences,Hefei. Anti - herpessimplexvirus 2 effect of nanometer class silicon dioxide[J]. Anhui Medical Journal, 2002, 23(6): 5-6. DOI: 10.3969/j.issn.1000-0399.2002.06.002 |
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| Authors: | Chen Guoliang Li Xiaoshang Shan Jingxuan et al Anhui Institute of Medical Sciences Hefei |
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| Affiliation: | Chen Guoliang,Li Xiaoshang,Shan Jingxuan,et al Anhui Institute of Medical Sciences,Hefei 230061 |
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| Abstract: | Objective To observe anti-herpessimplexvirus 2(HSV-2) effect of nanometer class silicon dioxide(SiO 2N-1,SiO 2N-2).Methods The virulence of HSV-2 was determined and the half tissue culture infective dose on cell (TCID 50 )was confirmed. Then the toxin of drug on cell was determined and the maximal nonotoxic concentration of durg(TCD 0) was confirmed. The medium effective dose of SiO 2N-1. SiO 2N-2 on cytopathic effect (CPE) was determined at last.Results The medium effective dose of SiO 2N-1(IC 50 ) was 1/3200 and the medium effective dose of SiO 2N-2(IC 50 ) was 1/8.Conclusion The SiO 2N-1,SiO 2N-2 has the effect of antiherpessimplexvirus 2. |
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| Keywords: | Silicon dioxide Herpes simplex virus 2 |
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