| 缺氧对耳蜗功能的影响 |
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| 引用本文： | 康颂建,杜君兰.缺氧对耳蜗功能的影响[J].泰山医学院学报,1992,13(1):39-42. |
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| 作者姓名： | 康颂建 杜君兰 |
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| 作者单位： | 泰山医学院生理学教研室,泰山医学院生理学教研室,泰安市中心医院,泰安市中心医院,泰安市中心医院 |
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| 摘 要： | 通过豚鼠自主呼吸闭路循环装置中的空气进行研究,其中呼出气中的CO_2被吸收。随着呼吸引起吸入气中O_2量逐渐降低,诱发动脉血PO_2下降。以耳蜗总和动作电位(CAP)为耳蜗功能衰变的指标,观察耳蜗功能衰变时的血PO_2值。结果表明平均动脉血PO_2降低到52kPa时,用短声阈上10dB(听力级)强度刺激引起CAP的N_1波波幅降低;动脉血PO_2降至4.3kPa时,所有的实验动物都发生了阈移。本研究提示平均动脉血PO_2在5.2kPa是豚鼠耳蜗功能衰变的阈值,并对其机制进行了探讨。
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| 关 键 词： | 耳蜗 呼吸 缺氧 |
COCHLEAR ACTION POTENTIALS AND SYSTEMIC ATERIAL PO_2 |
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| Kang Songjiun. Zhao Xiaoguang. Du Junlan. Sun Jiyou,Shi Yongzhi.COCHLEAR ACTION POTENTIALS AND SYSTEMIC ATERIAL PO_2[J].Journal of Taishan Medical College,1992,13(1):39-42. |
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| Authors: | Kang Songjiun Zhao Xiaoguang Du Junlan Sun Jiyou Shi Yongzhi |
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| Abstract: | A Progressive decrease in arterial PO_2 was induced by self-breathing of the air from a closed circuit instrument in guinea pigs. N_1 waves of cochlear action potential varied as the progressive decrease of the blood oxygen. A decreased magnitude of N_1 waves was observed only when the arterial blood PO_2 was on an average of 5.2kPa, and when the stimulus intensities were 10 dB above the threshold. Hearing threshold changeed in all the experimental animals when the arterial blood PO_2 fell to 4.3kPa. It is suggested that 5.2kPa should be the "critical level" at which cochlear function begin to fail in guinea pigs. |
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| Keywords: | anoxiz cochlea respiration |
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