| 卡托普利对自发性高血压大鼠血压及其靶器官脂质过氧化作用的影响 |
| |
| 引用本文： | 李辉,李俭春,江时森.卡托普利对自发性高血压大鼠血压及其靶器官脂质过氧化作用的影响[J].中国药理学通报,1994(5). |
| |
| 作者姓名： | 李辉 李俭春 江时森 |
| |
| 作者单位： | 南京军区总医院心脏科 |
| |
| 摘 要： | 用卡托普利治疗自发性高血压大鼠（ＳＨＲ），观察大鼠血压以及靶器官心、脑、肾组织脂质过氧化产物丙二醛（ＭＤＡ）含量及锰－超氧化物歧化酶（Ｍｎ－ＳＯＤ）活力的改变。结果表明，ＳＨＲ心、脑、肾组织ＭＤＡ含量增加，且Ｍｎ－ＳＯＤ活力增强，存在严重的脂质过氧化损伤。卡托普利对ＳＨＲ有显著的降压作用和减轻靶器官脂质过氧化损伤作用。
|
| 关 键 词： | 卡托普利，脂质过氧化物，锰－超氧 |
Effect of captopil on blood pressure and lipid peroxidation of myocardium, brain and kidney in sponteneously hypertensive rats |
| |
| LI Hut, LI Jian-Chun,JIANG Shi-Sen.Effect of captopil on blood pressure and lipid peroxidation of myocardium, brain and kidney in sponteneously hypertensive rats[J].Chinese Pharmacological Bulletin,1994(5). |
| |
| Authors: | LI Hut LI Jian-Chun JIANG Shi-Sen |
| |
| Abstract: | In sponteneously hyperten sive rats(SHR) treated with captopril,the blood pressure,lipid peroxides(MDA)and Mn-SOD activity in myocardium, brain and kidney tissues of the rats were determined.Both MDA content and Mn-SOD activity in myocardium,brain and kidney significantly increased. It is indicated that Captorpril plays and important role in reducing blood pressure and decreasing the damage from the effect of lipid peroxidation on myocardium,brain and kidney in SHR. |
| |
| Keywords: | captopril lipid peroxides Mn-SOD SHR |
| 本文献已被 CNKI 等数据库收录！ |
