趋化因子受体4、血管内皮生长因子在肝细胞肝癌的表达及临床意义

目的 探讨趋化因子受体4(chemokine receptor 4,CXCR4)和血管内皮生长因子(vascular endothelialgrowth factor,VEGF)在肝细胞肝癌(hepatocellular carcinoma,HCC)中的表达及其临床意义.方法 应用免疫组织化学方法检测CXCR4和VEGF在肝癌、癌旁及正常肝组织中的表达,并分析其与肝癌临床病理学特征的关系.结果 在肝癌组织CXCR4和VEGF的表达均显著高于癌旁及正常肝组织(56.5%,25.0%vs 0,76.7%,40.0%vs 0,P<0.05或<0.01);CXCR4和VEGF在肝癌转移的肿瘤组织中的表达高于无转移的肿瘤组织(85.7%vs 47.8%,100%vs 69.6%,均P<0.05);肝癌组织中CXCR4与VEGF的表达呈显著正相关(r=0.901,P<0.001).结论 CXCR4与VEGF可能在HCC的浸润转移中发挥着重要的协同作用.

Expression and clinical significance of chemokine receptor 4 and vascular endothelial growth factor in hepatocellular carcinoma

Objective To investigate the expression of chemokine receptor 4（CXCR4） and vascular endothelial growth factor（VEGF） in hepatocellular carcinoma（HCC） and their clinical significance. Methods The expression of ehemokine receptor 4 and vascular endothelial growth factor in HCC, peri-cancerous tissues and normal liver tissues were detected by immunohistochemical method. Statistical analysis was used to determine the relationship between their expressions and clinicopathological features. Results CXCR4 and VEGF were over-expressed in HCC tissues compared with those in peri-cancerous tissues and normal liver tissues（56.5% ,25.0% vs 0,76.7% ,40.0% vs 0, P 〈0.05 or 0.01）. The expressions of CXCR4 and VEGF in HCC accompanied by metastasis were higher than those in the primary tumor site without metastasis （85.7% vs 47.8%, 100% vs 69.6%, all P d0.05）. There was a positive relationship between VEGF and CXCR4 expression （rs = 0. 901, P = 0. 001 ）. Conclusion CXCR4 and VEGF may play a synergistic role in the invasion and metastasis of HCC.