丹红注射液对急性心肌梗死患者介入术后缺血-再灌注心肌的保护作用

目的 探讨丹红注射液对急性心肌梗死(AMI)患者经皮冠状动脉介入治疗(PCI)后再灌注损伤的保护作用及可能机制.方法 随机将AMI患者分为丹红注射液组(n=29)和对照组(n=30),丹红注射液组给予PCI+常规药物+丹红注射液治疗,对照组给予PCI+常规药物治疗.于PCI前及PCI后1、7、14天抽取静脉血,分别测定高敏C反应蛋白(hsCRP)及内皮素(ET),同时观察PCI后1、7、14天行心脏超声检查检测的左心室射血分数(LVEF)以及PCI后1、7天ST段回落率.结果 两组PCI后1天hsCRP均升高,术后7天hsCRP均降低,丹红注射液组较对照组降低更明显,(1.59±0.53)mg/L vs (4.52±0.76)mg/L(P<0.01);两组PCI后7、14天ET均降低,丹红注射液组较对照组降低更明显,7天(74.65±2.17)μg/L vs (82.82±2.16)μg/L(P<0.01),14天(64.65±4.19)μg/L vs (75.15±4.01)μg/L(P<0.01);两组PCI后7、14天LVEF均升高.丹红注射液组较对照组升高更明显,7天(51.31±1.90)%vs(49.97±2.45)%(P<0.01).14天(61.82±3.17)% vs (51.26±2.65)%(P<0.01);丹红注射液组PCI后7天心电图ST段回落率明显高于对照组,86.2% vs 66.7%(P<0.01).结论 丹红注射液具有抑制PCI后炎症、抗心肌缺血-再灌注损伤、保护内皮功能、改善心肌组织再灌注及抑制心肌重塑的作用.

Protective effects of Danhong injection on myocardium after reperfusion in patients with acute myocardium infarction

Objective To investigate the protective effects and machanism of Danhong injection on myocardium after percutaneous coronary intervention （PCI） in patients with acute myocardial infarction （AMI）. Methods AMI patients were randomly divided into two groups： treatment group （ n = 29） and control group （ n = 30）. Treatment group was given PCI ＋ Danhong injection and routine treatment,and control group was given PCI＋ routine treatment for two weeks. High-sensitivity-reactive protein（bsCRP） and plasma endothelin（ET） levels were examined on 1st day, 7th day and 14th day after PCI. At the same time, the change of left ventricular ejection（LVEF） was observed, and also the degree of ST segment resolution was observed on 1st day,Tth day after PCI. Results The 1st day after PCI,hsCRP in the patients of both groups increased. On the 7th day after PCI,hsCRP of both groups decreased. The two groups had significant difference,（1.59±0.53） mg/L vs （4.52±0.76） rag/L（ P 〈0.01）. On the 7th and the 14th day after PCI, ET in the patients of both groups decreased. Compared with that of control group, ET level in treatment group decreased significantly,on the 7th day ET （74.65±2.17） 9g/L vs （82.82±2.16） μg/L （ P 〈0.01）,on the 14th day ET （64.65±4.19） μg/L vs （75.15±4.01） μg/L （ P 〈0.01）. On the 7th day and 14th day after PCI,LVEF in the patients of both groups improved. Compared with control group, LVEF of treatment group was improved obviously,on the 7th day LVEF （51.31±1.90） % vs （49.97±2.45） % （ P〈0.01）,on the 14tb day I.VEF （61.82±3. 17） % vs （51.26±2.65） % （ P 〈0. 01）. On the 7tb day after PCI,the degree of ST segment resolution between two groups had significant difference,86.2% vs 66.7%（ P 〈0.01）. Conclusion Danhong injection can prevent myocardial ischemia- reperfusion,protect microvascullar endothelial function, restrain inflammatory reaction and inhibit the remodeling of cardiac myocyte,improve LVEF.