血浆纤维蛋白原与2型糖尿病患者下肢血管病变的关系

目的 探讨血浆纤维蛋白原(FIB)水平与2型糖尿病患者下肢血管病变相关性.方法 选择2型糖尿病患者240例,男132例,女108例,全部受试者均采用高分辨彩色多普勒超声检查判定下肢动脉病变程度,按下肢血管病变严重程度进行评分,所有入选病例分为2型糖尿病下肢血管病变组(病变组又分为轻度、中度和重度组)与非病变组,比较病变组与非病变组间血浆纤维蛋白原水平;同时根据纤维蛋白原水平,比较高纤维蛋白原水平和正常纤维蛋白原水平患者的下肢血管病变发生率及病变严重程度情况.结果 糖尿病下肢血管病变组纤维蛋白原水平显著高于非病变组(3.20±0.66)g、L VS(2.85±0.57)g、L(P＜0.01),高纤维蛋白原患者较正常纤维蛋白原的下肢血管病变发生率显著增加,病变程度更重(50.94%VS 26.20%,P＜0.05).结论 血浆纤维蛋白原升高是2型糖尿病下肢血管病变的重要危险因素之一.

Relation between blood fibrinogen and lower extremity vasculopathy in type 2 diabetic patients

Objective To investigate the association of blood fibrinogen and lower extremity vasculopathy in type 2 diabetic patients. Methods 240 patients diagnosed type 2 diabetes mellitus included 132 males and 108 females were chosen. All of them received high-resolution color Doppler ultrasonography of lower extremity arteries, and the score was counted. According to the degree of lower extremity vasculopathy, the patients were divided into lower extremity vasculopathy group and non-diseased normal group. Among the lower extremity vasculopathy group, the patients were then divided into mild, midrange and severe group. Furthermore, the prevalence and the process severity of lower extremity vasculopathy were compared in the high and normal blood fibrinogen groups. Results The level of blood fibrinogen in the lower extremity vasculopathy group was significantly higher than that in non-diseased normal group （3.20±0.66） g/L vs （2.85±0.57） g/L（ P 〈0.05）. Compared with that of normal blood fibrinogen group,the prevalence of lower extremity vasculopathy was increased and the disease severity was more serious in the lower extremity vasculopathy group （50.94% vs 26.20%, P 〈0.05）. Conclusion The increased blood fibrinogen is one of the important risk factors in lower extremity vasculopathy with type 2 diabetic patients.