C反应蛋白在大肠癌早期诊断中的价值

目的 探讨C反应蛋白(CRP)与大肠癌发病的关系.方法 回顾性分析180例大肠癌,84例大肠腺瘤、36例肠镜正常者CRP和肿瘤标志物表达结果.结果 血清CRP和癌胚抗原(CEA)、糖类抗原12-5(CA12-5)、糖类抗原19-9(CA19-9)在大肠癌组表达强度和阳性率明显高于大肠腺瘤组和肠镜正常组(P<0.01或<0.05).大肠癌组内上述指标的表达强度为Ⅲ、Ⅳ期>Ⅰ、Ⅱ期(P<0.01或<0.05),阳性率为Ⅲ、Ⅳ期>Ⅰ、Ⅱ期(P<0.05),而Ⅲ、Ⅳ期之间阳性率差异无统计学意义(P>0.05).大肠癌Ⅰ、Ⅱ期CRP阳性率高于CEA、CA12-5、CA19-9的阳性率,Ⅰ期40.0% vs 5.0%、10.0%、5.0%(P<0.05),Ⅱ期66.1% vs 27.4%、37.1%、35.5%(P<0.01),而在大肠癌Ⅲ、Ⅳ期中上述比较差异无统计学意义(P>0.05).结论 CRP对大肠癌早期诊断具有临床价值,临床医生不应忽略CRP持续升高患者在排除其他升高原因后有潜在肿瘤的可能性,应尽早作进一步检查.

Exploration of relationship between C-reactive protein and colorectal cancer

Objective To find the the relationship between C-reactive protein and colorectal cancer. Methods The levels of CRP and tumor markers were measured in 180 patients with colorectal cancer, 84 patients with colorectal adenoma, 36 healthy controls, all of which were confirmed with colonoscope and pathological examinations. Results Positive rate and intensity of CRP and tumor marker expression in colorecta] cancer were higher than those of the colorectal adenoma and healthy, the CRP and tumor marker expression intensity in the colorectal cancer were arranged in order as stage Ⅲ ,stage Ⅵ〉stage Ⅰ ,stage Ⅱ ,hut the positive rate was stage Ⅲ,stage Ⅵ〉stage Ⅰ ,stage Ⅱ ,there was no significant difference between stage Ⅲ and stage Ⅵ, CRP compared with CEA,CA12-5, CA19-9 in stage 40.0% vs 5.0%,10.0%,5.0%,in stage Ⅱ66.1% vs 27.4%,37.1%,35.5%（P〈0.01）.In the stage Ⅰ and stage Ⅱ CRP positive rate was higher than the tumor markers,but it was no significant difference in the stage Ⅲ and stage Ⅵ. Conclusion CRP is important in the early diagnosis of colorectal cancer, doctors should pay attention to the relationship between the CRP increasing and the potential tumor.