Cox多元回归分析对比药物洗脱支架与单纯球囊扩张术在急性心肌梗死小血管罪犯病变中应用效果

目的 探讨急性,心肌梗死小血管罪犯病变的介入治疗中,与应用单纯球囊扩张术相比,药物洗脱支架的安全性与有效性.方法 共入选1364例罪犯血管为小血管病变(靶血管直径≤2.5 mm)的急性心肌梗死并接受成功经皮冠状动脉介入治疗(PCI)的患者,根据治疗方案分为药物洗脱支架组(支架组,n=683)和单纯球囊扩张组(球囊扩张组,n=681),应用Cox多元回归分析对比两组患者随访8个月时的主要不良心脏事件的发生情况.结果 支架组与球囊扩张组相比,心源性病死率优势比(OR)0.57,95%可信区间(CI)0.33～0.98,P=0.041]和总病死率(OR 0.60,95%CI 0.38～0.95,P=0.028)显著降低,其他主要不良心脏事件发生率两组间无统计学差异.结论 小血管病变急性心肌梗死患者即使靶血管已成功开通,植入药物洗脱支架也是必要的.

Comparison of implantation of drug-eluting stent with balloon angioplasty only in small target vessels in patients with acute myocardial infarction using multivariable cox regression analysis

Objective To compare the safety and efficacy of drug-eluting stent(DES) implantation with balloon angioplasty only in small target vessels of patients with acute myocardial infarction(AMI).Methods A total of 1 364 AMI patients who received successful percutaneous coronary intervention(PCI) in small target vessels were enrolled.Patients were divided into DES therapy group(stenting group,n=683) and balloon angioplasty only group(ballooning group,n=681).Various major adverse cardiac events at 8 months were com...