| 亚硒酸钠等三种药物对肝癌高发区饮用塘水诱变活性的抑制效果观察 |
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| 引用本文： | 张丽生 梁干旺. 亚硒酸钠等三种药物对肝癌高发区饮用塘水诱变活性的抑制效果观察[J]. 癌症, 1991, 10(2): 118-120 |
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| 作者姓名： | 张丽生 梁干旺 |
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| 作者单位： | 广西肿瘤研究所，广西肿瘤研究所，广西扶绥县肝癌研究所，广西扶绥县肝癌研究所，广西扶绥县肝癌研究所 南宁 530000，南宁 530000 |
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| 摘 要： | 用紫露草微核试验,观察了亚硒酸钠(Na_2SeO_3)、维生素C(VC)、谷胱甘肽(GSH)等三种化学药物对扶绥县肝癌高发区饮用塘水诱变活性的抑制效果及剂量一效应关系。当受试药物加入浓度为0.01MM时,塘水诱发的紫露草微核效应受到明显抑制,其效果以Na_2SeO_3最佳,VC居次,GSH较弱。作者设想,将Na_2SeO_3作为肝癌高发区饮用塘水的一项干预措施,有可能达到既改水又补硒的双重效果。
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| 关 键 词： | 亚硒酸钠 抗诱变性 肝肿瘤 塘水 |
INHIBITION OF SODIUM SELENITE, VITAMINC AND GLUTATHION ON THE MUTAGENIC EFFECTS OF POOL WATER IN HEPATOCELLAR CARCINOMA HIGH INCIDENCE AREA |
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| ZHANG Li-sheng HUANG Shao-zhen. INHIBITION OF SODIUM SELENITE, VITAMINC AND GLUTATHION ON THE MUTAGENIC EFFECTS OF POOL WATER IN HEPATOCELLAR CARCINOMA HIGH INCIDENCE AREA[J]. Chinese journal of cancer, 1991, 10(2): 118-120 |
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| Authors: | ZHANG Li-sheng HUANG Shao-zhen |
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| Abstract: | Using tradescantia micronucteus test, the inhibition and dose-effect relationship of sodium selenite (Na 2 SeO3), vitamin C(VC) and glutathion (GSH) on the mutagenic effect induced by pool water in hepatocellular carcinoma (HCC) high incidence area-Fusui county was studied. An obvious inhibition of Tradescantia micronucleus response was observed when the aforementioned reagents were added into the pool water at a concentration of 0.01 mM and the highest inhibition response was induced by Na2 SeO3. Therefore, sodium selenite may be used as an interventive agent in HCC high incidence area. This measure may have dual actions: improvement of the quality of water and supplement of selenium. |
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| Keywords: | sodium selenite antimutagenicity drinking pool water Tradescantia micronucteustest. |
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