| 动态观察抗纤灵冲剂对单侧输尿管梗阻及再通后大鼠血脂变化的影响 |
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| 引用本文： | 吴锋,张新志,黄迪,董飞侠,何立群. 动态观察抗纤灵冲剂对单侧输尿管梗阻及再通后大鼠血脂变化的影响[J]. 中华中医药杂志, 2011, 0(4): 675-678 |
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| 作者姓名： | 吴锋 张新志 黄迪 董飞侠 何立群 |
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| 作者单位： | 上海中医药大学附属曙光医院肾内科肝肾疾病病证教育部重点实验室上海市高校中医内科研究院; |
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| 基金项目： | 国家自然科学基金项目(No.30873259); 上海市优秀学科带头人培养计划(No.08XD14039); 上海市教育委员会E-研究院建设计划(No.E03008); 上海高校创新团队建设项目~~ |
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| 摘 要： | 目的:研究单侧输尿管梗阻(UUO)及再通后大鼠血脂的变化和抗纤灵对血脂变化的影响。方法:建立大鼠UUO模型120只和UUO再通模型90只,随机分为正常组、假手术组、模型组、抗纤灵组和科素亚组。于造模后各时间点检测TC、TG、HDL-C和LDL-C。结果:在UUO模型中,模型组TC、TG、LDL-C随梗阻时间的延长逐渐升高,在28d时与正常组和假手术组比较有显著差异;HDL-C随梗阻时间的延长逐渐降低,在21d、28d时与正常组和假手术组比较有显著差异。在UUO再通模型中,模型组TC、LDL-C逐步升高,再通21d时与正常组和假手术比较差异有显著性;HDL-C逐渐降低,与正常组和假手术组相比,再通14d、21d时差异显著。与模型组比较,抗纤灵能降低TC、TG、LDL-C,升高HDL-C。结论:抗纤灵冲剂能改善UUO模型和UUO再通模型中的脂代谢紊乱。
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| 关 键 词： | 抗纤灵冲剂 单侧输尿管梗阻 单侧输尿管梗阻后再通 血脂 |
Effects of Kangxianling Decoction on lipid in rat after unilateral ureteral obstruction and recanalization |
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| WU Feng,ZHANG Xin-zhi,HUANG Di,DONG Fei-xia,HE Li-qun. Effects of Kangxianling Decoction on lipid in rat after unilateral ureteral obstruction and recanalization[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2011, 0(4): 675-678 |
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| Authors: | WU Feng ZHANG Xin-zhi HUANG Di DONG Fei-xia HE Li-qun |
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| Affiliation: | WU Feng,ZHANG Xin-zhi,HUANG Di,DONG Fei-xia,HE Li-qun(Nephrology Department of Shuguang Hospital Affiliated to Shanghai University of TCM,Education Ministry Key Laboratory of Liver and Kidney Disease Syndrome,E-Institute of Internal Medicine of TCM,Higher Education in Shanghai,Shanghai 201203,China) |
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| Abstract: | Objective:To explore effects of Kang Xian Ling Decoction on lipid in rat after unilateral ureteral obstruction and recanalization.Methods:120 male Sprague-Dawley rats in UUO model and 90 male Sprague-Dawley rats in UUO recanalization model were randomly divided into 5 groups:normal group,shame-operated group,model group,KXL group,and Lostartan group.TC,TG,HDL-C and LDL-C were tested weekly.Results:In UUO model,TC,TG,LDL-C in model group increased gradually,compared with those in normal group and group and s... |
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| Keywords: | Kang Xian Ling Decoction Unilateral ureteral obstruction Recanalization after unilateral ureteral obstruction Lipid |
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