| 化痰与活血方对非酒精性脂肪肝氧应激的影响 |
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| 引用本文： | 夏蓉,车念聪,袁梦,季巍巍,法振鹏. 化痰与活血方对非酒精性脂肪肝氧应激的影响[J]. 中华中医药杂志, 2011, 0(2): 260-263 |
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| 作者姓名： | 夏蓉 车念聪 袁梦 季巍巍 法振鹏 |
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| 作者单位： | 首都医科大学中医药学院; |
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| 基金项目： | 北京市教育委员会科技计划面上项目(No.KM200810025028)~~ |
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| 摘 要： | 目的:观察化痰方与活血方对非酒精性脂肪肝(NAFLD)大鼠氧应激损伤的影响,探讨两方在NAFLD治疗中的作用。方法:制备NAFLD大鼠模型,同时用化痰方和活血方对模型进行干预,并与西药组(二甲双胍+罗格列酮)进行对照,设置正常组、模型组、西药组、化痰方组、活血方组及合方组共6组,检测肝组织CYP450及CYP2E1活性,测定SOD、MDA。结果:模型组的CYP450和CYP2E1活性增强(P<0.05),SOD活性下降(P<0.05),MDA含量升高(P<0.01);所有中药组均能降低CYP2E1活性(P<0.05),而西药组能降低CYP450活性(P<0.05);化痰方与活血方能够提高SOD活性(P<0.01),降低MDA含量。结论:NAFLD大鼠存在明显的氧应激和脂质过氧化损伤情况,化痰方与活血方均能不同程度地调节NAFLD大鼠的氧应激水平,改善脂质过氧化,对NAFLD具有确切的防治作用。
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| 关 键 词： | 非酒精性脂肪肝 氧应激 化痰方 活血方 实验研究 |
Experimental study on effect of Huatan,Huoxue decoctions on oxidative stress in non-alcoholic fatty liver rats |
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| XIA Rong,CHE Nian-cong,YUAN Meng,JI Wei-wei,FA Zhen-peng. Experimental study on effect of Huatan,Huoxue decoctions on oxidative stress in non-alcoholic fatty liver rats[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2011, 0(2): 260-263 |
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| Authors: | XIA Rong CHE Nian-cong YUAN Meng JI Wei-wei FA Zhen-peng |
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| Affiliation: | XIA Rong,CHE Nian-cong,YUAN Meng,JI Wei-wei,FA Zhen-peng(College of TCM,Capital Medical University,Beijing 100069,China) |
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| Abstract: | Objective:TO observe the effect of Huatan decoction and Huoxue decoction on oxidative stress in rat model of non-alcoholic fatty liver disease,discussing the efficacy of these two decoctions in the prevention and treatment of NAFLD.Materials and Methods: Experimental animal model of NAFLD were established,treated with Huatan,Huoxue decoctions,and compared with the control group,the model group and the treatment group in which rats were treated with insulin sensitizer-Metformin and Rosiglitazone.Test CYP450,... |
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| Keywords: | Non-alcoholic fatty liver Oxidative stress Huatan decoction Huoxue decoction Experimental study |
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