Evaluation of the combination 5-fluorouracil, dacarbazine, and epirubicin in patients with advanced well-differentiated neuroendocrine tumors |
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Authors: | Walter Thomas Bruneton Domitille Cassier Philippe A Hervieu Valérie Pilleul Frank Scoazec Jean Yves Chayvialle Jean Alain Lombard-Bohas Catherine |
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Institution: | 1. Department of Medical Oncology, Kobe City Medical Center General Hospital, Kobe, Japan;2. Department of Surgery, Kobe City Medical Center General Hospital, Kobe, Japan;3. Department of Clinical Oncology, Kagawa University Hospital, Kagawa, Japan;4. Department of Pathology, Kobe City Medical Center General Hospital, Kobe, Japan;5. Division of Biostatistics, Clinical Research Center, Aichi Medical University, Nagoya, Japan;6. Gastrointestinal Cancer Center, Sano Hospital, Kobe, Japan;7. Department of Surgery, Kansai Rosai Hospital, Hyogo, Japan |
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Abstract: | IntroductionThe aim of this study was to retrospectively analyze the efficacy and safety of the combination of 5-fluorouracil (5-FU), dacarbazine, and epirubicin (FDE) in 39 patients with advanced, well-differentiated neuroendocrine tumors (NETs).Patients and MethodsThe primary sites of the disease were the pancreas (16 cases), gastrointestinal tract (12 cases), and extradigestive sites (11 cases). Out of these, 54% of the patients were chemotherapy naive and 74% were progressive. The treatment was a combination of 5-FU 500 mg/m2/day, dacarbazine 250 mg/m2/day for 5 days, and epirubicin 50 mg/m2 on day 1, administered every 21 days. Tumoral response was assessed with response evaluation criteria in solid tumors.ResultsPartial response was seen in 17 out of the 39 patients (44%) and the median response duration was 12 months. The median progression-free survival and overall survival were 11 and 21 months, respectively. Disease control was achieved in 83% of the 29 patients in progression at the beginning of the treatment. Objective responses were 58%, 25%, and 36%, for pancreatic, gastrointestinal, and extradigestive NETs, respectively. The sole grade 3/4 toxicity was hematologic.ConclusionThe FDE regimen is effective in advanced well-differentiated NETs and represents an interesting alternative to streptozocin-based regimens as first- or second-line therapy. |
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