冠心病患者检测高敏C反应蛋白的临床意义

目的探讨高敏C反应蛋白(hs-CRP)浓度变化与冠状动脉的病变程度及硬化斑块的稳定性之间的关系及临床意义。方法经冠状动脉造影确诊冠心病患者90例,按照其造影结果分为单支病变组(35例)、双支病变组(35例)和三支病变组(20例),观察hs-CRP水平与冠脉病变的关系,并分析稳定型心绞痛(SA)组、不稳定型心绞痛(UA)组及心肌梗死(AMI)组hs-CRP水平的关系。结果双支病变组及三支病变组中hs-CRP浓度比单支病变组显著升高(P<0.01)。双支病变组和三支病变组之间的差异有统计学意义(P<0.01)。UA组及AMI组的hs-CRP水平比SA组明显升高,AMI组比UA组显著升高。结论 hs-CRP水平与冠脉病变的程度及硬化斑块的稳定性有密切的联系,可作为冠心病患者判断病情严重程度的指标。

Clinical value of hs-CRP detection in patients with coronary heart disease

Objective To study the relationship and clinical value between high sensitivity C-reactive protein （hs-CRP） level and the severity of coronary artery and the stability of atherosclerotic plaque. Methods A total of 90 patients with coro nary heart disease （CHD） who underwent coronary angio-graphy （CAG） were divided into 1 vessel disease group （n=35）, 2 vessel-disease group （n= 35） and 3-vessel disease group （n= 20） . The relationship between hs-CRP and the severity of coro- nary artery, and the relationship of hs-CRP levels in the stable angina （SA） group, the unstable angina （UA） group and the a- cute myocardial infarction （AMI） group were analyzed. Results The hs-CRP levels were higher in the 2-vessel-disease group and the 3-vessel-disease group than that in the 1-vessel-disease group. There was statistics difference in the three groups （P~ 0.01）. There was statistics difference between the 2-vessel-disease group and the 3-vessel-disease group （P~0.01） . The hs- CRP levels were higher in the unstable angina （UA） group and the AMI group than that in the stable angina （SA） group. It was higher in the AMI group than in the unstable angina （UA） group. There was statistics difference in the three groups. Con- clusion The hs-CRP level is closely associated with the severity of coronary artery and the stability of atheroscierotic plaque. Hs-CRP is an indication for the severity of patients with CHD.