糖尿病肾病患者同型半胱氨酸和C反应蛋白检测的临床意义

目的探讨糖尿病肾病（DN）患者血清同型半胱氨酸（Hcy）及C反应蛋白（CRP）的变化及临床意义。方法2型糖尿病患者103例，根据尿微量白蛋白排泄率分为单纯糖尿病组（SDM组），早期DN组（EDN组），临床DN组（CDN组），30例健康体检者为健康对照组。测定Hcy和CRP水平。结果SDM组、EDN组和CDN组血清Hcy、CRP水平较健康对照组明显升高（P均〈0．05）；SDM组、EDN组和CDN组血清Hcy、CRP水平依次升高，组间比较差异有统计学意义（P均〈0．05）。结论Hcy、CRP随着DN病情进展，浓度逐渐升高，二者可作为DN病情的监测指标。

Clinical significance of homocysteine and C-reactive protein in diabetic nephropathy

Objective To explore the clinical significance of serum homocysteine （Hcy） and C-reactive protein （CRP）in diabetic nephropathy （DN）. Methods According to the results of urinary albumin excretion rate, 103 patients with type 2 diabetes mellitus were divided into simple diabetic mellitus group （SDM group）, early diabetic nephropathy （EDN group） and clinical diabetic nephropathy （ CDN group）. And thirty healthy people were enrolled as control group. Plasma Hcy and CRP were detected. Results Hcy, CRP in SDM group, EDN group and CDN group were all significantly higher than that of control group （ all P 〈 0.05）. The levels of SDM group, EDN group and CDN group increased successively. Significant differences existed between SDM group.EDN group and CDN group（ all P 〈 0.05）. Conclusion Increased Hcy and CRP might be related to the progression of DN. They could be used as the pathogenetic condition monitoring indexes for diabetic nephropathy.