A case of an unclassified tumor closely resembling dysembryoplastic neuroepithelial tumor with rapid growth |
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Authors: | Masao Nakatsuka Shirou Mizuno Tomohiro Kimura Kazuo Hara |
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Institution: | (1) Department of Neurosurgery, Chita Kousei Hospital, Japan;(2) Department of Neurosurgery, Nagoya City University, Japan;(3) Division of Pathology, Aichi Medical University Hospital, 81-6 Nishitani Kouwa Mihama-chou, 470-2404 Chita-gun Aichi-ken, Japan |
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Abstract: | We describe a rare case of a tumor resembling dysembryoplastic neuroepithelial tumor. A 3-year-old girl had a generalized
convulsion as the initial symptom, without other neurological deficits. Computed tomography showed a hypodense lesion with
calcific hyperdensity in the left frontal lobe associated with deformity of the overlying calvarium. Four months later, she
had a second seizure, and computed tomographic scan showed that the lesion had increased in size. Subtotal removal of the
tumor was performed, and the postoperative course was uneventful without radiation therapy. Histological examination revealed
a cortical lesion in which an oligodendrocyte-like area and an astrocyte-like area with cytological atypia were observed.
Although the clinical course and the radiological findings closely resembled those of dysembryoplastic neuroepithelial tumor,
specific glioneuronal elements were not found histologically. Daumas-Duport reported a complex form of dysembryoplastic neuroepithelial
tumor that contained glial nodules in addition to a specific glioneuronal element. The histological findings of the glial
nodules in this case were quite similar to those she described. We conclude that this could be an unclassified tumor closely
resembling dysembryoplastic neuroepithelial tumor without a specific glioneuronal element.
This case was registered at the Japan Brain Tumor Reference Center (No. 98-012) |
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Keywords: | Dysembryoplastic neuroepithelial tumor Rapid growth Cortical lesion Epilepsy Specific glioneuronal element |
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