幽门螺杆菌感染与儿童感染胃炎的关系探讨

目的 进一步探讨幽门螺杆菌(H·pylori)感染在儿童中发病率以及家庭中的传播关系.方法 将我院2000年1月至2005年12月87例儿童胃炎,其中住院20例,门诊67例,做胃镜检查,并做病理学检查,胃黏膜H·pylori的检测.H·pylori阳性44例,H·pylori阴性43例.结果 表明H·pylori感染与儿童胃炎有密切的关系,H·pylori阳性家庭中的感染率为77.3%,H·pylori阴性家庭中的感染率44.2%,有显著差异性(P＜0.01).胃镜检查显示慢性浅表性胃炎52.87%,十二指肠球部溃疡19.54%,病理学检查显示慢性浅表性胃炎在H·pylori阳性组轻度占23%,中度50%,在H·pylori阴性组轻度占70%,中度占23%,两组比较有显著差异性(P＜0.01).结论 H·pylori感染呈现明显家庭群聚现象.胃黏膜病理变化H·pylori阳性组比H·pylori阴性组严重.

The investigation of the relationship between the Helicobacter pylori infection and gastritis in children

Objective To investigate the relationship between Helicobacter pylori(HP) infection andgastritis in children and HP transmission among family members.Methods During January 2000 to December 2005,87 children with gastrictis in our hospital including 20 inpatients and 67 outpatients,were examined by gastroscope,pathologyand HP test in gastric mucosa.Results There were 44 HP positive cases and 43 HP negative cases.HP infection was closely related with gastritis in children.The infection rate in HP positive family was 77.3%,however,which was 44.3% in HP negative family.There was a significant difference between the two groups(P<0.01).The gastroscopic examination showed that the incidence of children superficial gastritis was 52.87%.The morbidity of duodenal ulcer was 19.54%.The pathological examination indicated that in HP positive group the morbidity of mild chronic superficial gastritis was 23%,whereas the morbidity of moderate gastritis was 50%.However in HP negative group the morbidity was 70% and 23% respectively.There was a significant difference between the two groups(P<0.01).Conclusion HP infection has the trend offamily conglutination,and the pathological changes in gastric mucosa are more severe in HP positive group than those in HPnegative group.