| ISOLATION AND CHARACTERIZATION OF AN ADRIAMYCIN－RESISTANT SUBLINE OF THE HUMAN GASTRIC ADENOCARCINOMA CELLLINE |
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| 引用本文： | 王艳萍,徐刚.ISOLATION AND CHARACTERIZATION OF AN ADRIAMYCIN－RESISTANT SUBLINE OF THE HUMAN GASTRIC ADENOCARCINOMA CELLLINE[J].中国癌症研究,1994,6(3):177-183. |
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| 作者姓名： | 王艳萍 徐刚 |
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| 作者单位： | Institute of Cancer Research，West China University of Medical Sciences，Chengdu 610041 |
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| 摘 要： | ＩＳＯＬＡＴＩＯＮＡＮＤＣＨＡＲＡＣＴＥＲＩＺＡＴＩＯＮＯＦＡＮＡＤＲＩＡＭＹＣＩＮ－ＲＥＳＩＳＴＡＮＴＳＵＢＬＩＮＥＯＦＴＨＥＨＵＭＡＮＧＡＳＴＲＩＣＡＤＥＮＯＣＡＲＣＩＮＯＭＡＣＥＬＬＬＩＮＥＷａｎｇＹａｎｐｉｎｇ；王艳萍；ＸｕＧａｎｇ；徐刚（Ｉ...
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| 修稿时间： | 19 May 1993 |
Isolation and characterization of an adriamycin-resistant subline of the human gastric adenocarcinoma cell line |
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| Wang Yanping,Xu Gang.Isolation and characterization of an adriamycin-resistant subline of the human gastric adenocarcinoma cell line[J].Chinese Journal of Cancer Research,1994,6(3):177-183. |
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| Authors: | Wang Yanping Xu Gang |
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| Institution: | (1) Institute of Cancer Research, West China University of Medical Sciences, 610041 Chengdu |
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| Abstract: | An adiamycin( ADM)- resistant human gastric adenocarcinoma cell subline SGC- 790 1 /AR was obtained by Intermitten stepwise selection in increasing concentration of drug from the parent cell line SGC- 7901. The resistant cells were 25 fold more resistant to ADM and displayed a multidrug-resistant phenotype. Compared to the parent cells, SGC- 7901/ AR cells had some remarkably altered biological properties; cellular content of ADM was reduced by approximately a half; the distribution of intracellular ADM had been changed. This resistant cells may be used as an experimental system for the study of mechanisms of drug resistance and the measures for overcoming drug-resistance |
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| Keywords: | Resistance to drugs Adriamycin Humangastric adenocarcinoma Cell subine |
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