我院围术期预防用抗菌药物的干预效果分析

目的:探讨对围术期预防用抗菌药物的药学干预,促进临床合理用药。方法:选取我院2011年7-12月外科围术期500份病历作为非干预组;在实施一系列药学干预措施后,另选取2012年1-6月外科围术期500份病历作为干预组。分析两组患者预防用抗菌药物情况。结果:干预组患者抗菌药物应用率由84.80%下降为29.60%,选药以第1代头孢菌素为主,术前0.5～2h预防用药比例由77.59%提高到94.59%,其他不合理应用现象较非干预组明显减少。结论:围术期实施药学干预,可以强化临床医师合理应用抗菌药物的意识,提高合理用药水平,明显降低围术期预防用抗菌药物的应用率,缩短抗菌药物应用疗程。

Effects of Pharmaceutical Intervention on Perioperative Prophylactic Application of Antibiotics in Our Hos- pital

OBJECTIVE： To explore the effects of pharmaceutical intervention on intervention drug use during perioperative period, and to promote rational use of drugs in the clinic. METHODS： 500 medical cases from Jul. to Dec. in 2011 were selected as non-intervention group; other 500 cases from Jan. to Jun. in 2012 were selected as intervention group in surgical department during perioperative period after the implementation of pharmaceutical intervention. The prophylactic application of antibiotics in 2 groups were analyzed. RESULTS： The utilization ratio of antibiotics in intervention group decreased from 84.80% to 29.60%, mainly were first-generation cephalosporins; prophylactic drug use 0.5-2 h before operation increased from 77.59% to 94.59%; and the other unreasonable drug use was significantly reduced, compared with nonintervention group. CONCLUSIONS： Perioperative pharmaceutical intervention is able to improve the consciousness of doctors to prescribe antibiotics reasonably and the level of rational drug use, significantly reduce the rate of perioperative prophylactic application of antibiotics, as well as shorten the treatment course of antibiotics.