Induction of ovulation with pulsatile GnRH: comparison between subcutaneous and intravenous administration in the same patients |
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Authors: | A Riolo E Carioni S Lerro M Albano A Crippa D Gelli M Bini P Pisoni |
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Institution: | Endocrinology Department, Niguarda Hospital, Cà Granda, Milan. |
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Abstract: | In this study we compared the results obtained during GnRH pulsatile therapy for ovulation induction in the same patients receiving successively GnRH by subcutaneous (10 mcg/90') and intravenous route (2.5 or 5 mcg/90'). Our data suggest that intravenous administration is the most effective procedure for restoring fertility, either in terms of hormonal levels (oestradiol and gonadotropin peaks) or ovulation rate (100% of ovulatory cycles on GnRH treatment versus 25% on subcutaneous administration). With regard to intravenous GnRH therapy, the dose of 2.5 mcg/90' may be more advisable and safe from ovarian overstimulation. |
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