Serum vitamin D level is negatively associated with carotid atherosclerosis in Korean adults |
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Authors: | Yeon-Kyeong Choi Sang-Wook Song Bo-Ra Shin Jeong-Ah Kim |
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Institution: | Department of Family Medicine, St. Vincent’s Hospital, College of Medicine, the Catholic University of Korea, Seoul, Republic of Korea |
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Abstract: | The present study investigated the associations between serum vitamin D levels and carotid intima-media thickness (CIMT), carotid plaque and atherosclerosis in 71 Korean adults. CIMT and the presence of carotid plaque were assessed with a high-resolution B-mode ultrasound system, and carotid atherosclerosis was defined as a mean CIMT value >0.9?mm or the presence of carotid plaque. A vitamin D deficiency was associated with the presence of carotid plaque (adjusted odds ratio aOR]: 9.25, 95% confidence interval CI]: 1.52–56.3; p?=?0.016). As serum vitamin D levels increased, the presence of high-risk carotid plaque decreased (aOR: 0.84, 95%CI: 0.72–0.99; p?=?0.039). Serum vitamin D levels was negatively associated with carotid atherosclerosis (aOR: 0.86, 95%CI: 0.76–0.97; p?=?0.018). Further studies are needed to investigate whether vitamin D supplementation would be effective for the prevention of atherosclerosis and cardiovascular diseases. |
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Keywords: | Carotid intima-media thickness carotid plaque vitamin D deficiency 25-hydroxyvitamin D |
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