Y-Chromosomal effects on discrimination learning and hippocampal asymmetry in mice |
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| Authors: | J. H. F. van Abeelen C. J. J. G. Janssens W. E. Crusio W. A. J. G. Lemmens |
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| Affiliation: | (1) Department of Animal Physiology, University of Nijmegen, Toernooiveld, 6525 ED Nijmegen, The Netherlands;(2) Institut für Humangenetik und Anthropologie, Universität Heidelberg, Im Neuenheimer Feld 328, 6900 Heidelberg, FRG;(3) Department of Statistical Consultation, University of Nijmegen, Toernooiveld, 6525 ED Nijmegen, The Netherlands |
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| Abstract: | From a four-way cross between unrelated inbred strains of mice, a random-breeding line was developed that segregated at two coat-color loci and carried Y chromosomes from different sources. Adult males were used for measurements of black-white discrimination learning and 7-day response retention in a water maze, body weight, brain weight, and left- and right-side hippocampus weight. Clear evidence was obtained of Y-linked influences on response acquisition, body weight, right-side hippocampus weight, and hippocampal asymmetry, whereas direct effects of autosome 9 were indicated with regard to right-side hippocampus weight only. However, epistatic interactions of the Y chromosome with autosome 9 were found for response acquisition and body weight and with autosome 4 for hippocampal asymmetry. |
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| Keywords: | Y chromosome autosomes heterogeneous line discrimination learning hippocampus mice |
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