Sequencing the transcriptional network of androgen receptor in prostate cancer |
| |
| Authors: | Kern Rei Chng Edwin Cheung |
| |
| Affiliation: | 1. Cancer Biology and Pharmacology, Genome Institute of Singapore, A*STAR (Agency for Science, Technology and Research), Singapore 138672, Singapore;2. Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore;3. School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore;4. Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore 117573, Singapore |
| |
| Abstract: | The progression of prostate cancer is largely dependent on the activity of the androgen receptor (AR), which in turn, correlates with the net output of the AR transcriptional regulatory network. A detailed and thorough understanding of the AR transcriptional regulatory network is therefore critical in the strategic manipulation of AR activity for the targeted eradication of prostate cancer cells. In this mini-review, we highlight some of the novel and unexpected mechanistic and functional insights of the AR transcriptional network derived from recent targeted sequencing (ChIP–Seq) studies of AR and its coregulatory factors in prostate cancer cells. |
| |
| Keywords: | Chromatin immunoprecipitation High-throughput sequencing Androgen receptor Prostate cancer Transcriptional network |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
