Multistage delivery of chemotherapeutic nanoparticles for breast cancer treatment |
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Authors: | Elvin Blanco Takafumi Sangai Angela Hsiao Silvia Ferrati Litao Bai Xuewu Liu Funda Meric-Bernstam Mauro Ferrari |
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Affiliation: | 1. Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, TX 77030, United States;2. Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States |
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Abstract: | Adequate drug delivery to tumors is hindered by barriers such as degradation and non-specific distribution. Nested incorporation of drug-containing nanoparticles within mesoporous silicon particles (MSVs), carriers rationally designed to enhance tumor transport, was hypothesized to result in pronounced and sustained antitumor efficacy. Paclitaxel (PTX)-containing poly(ethylene glycol)-block-poly(ε-caprolactone) (PEG-PCL) polymer micelles were favorably loaded within MSVs, after which drug release was significantly delayed. Antitumor efficacy analyses in mice bearing MDA-MB-468 breast tumors demonstrated significant tumor growth suppression following a single administration. Results highlight effective chemotherapeutic shuttling and site-specific controlled release afforded by MSVs, potentially translating towards improvements in patient outcomes and morbidity. |
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Keywords: | Cancer nanomedicine Multistage drug delivery Mesoporous silicon particles Polymer micelles Paclitaxel |
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