Profiles of circulating inflammatory cytokines in colorectal cancer (CRC), high cancer risk conditions,and health are distinct. Possible implications for CRC screening and surveillance |
| |
| Authors: | Malgorzata Krzystek-Korpacka Dorota Diakowska Bartosz Kapturkiewicz Marek Bębenek Andrzej Gamian |
| |
| Affiliation: | 1. Department of Medical Biochemistry, Wroclaw Medical University, Wroclaw, Poland;2. Department of Gastrointestinal and General Surgery, Wroclaw Medical University, Wroclaw, Poland;3. First Department of Oncological Surgery of Lower Silesian Oncology Center, Wroclaw, Poland;4. Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland |
| |
| Abstract: | Alternate colorectal cancer (CRC) screening and surveillance strategies are needed to pre-select candidates for invasive methods. We compared systemic inflammatory profiles in CRC (n = 99), health (n = 98), high CRC-risk conditions (n = 48) and overt inflammation (n = 69) by multiplexed analysis of IL-1β, IL-6, IL-8, FGF-2, G-CSF, GM-CSF, MCP-1, MIP-1α, TNF-α, VEGF-A, and PDGF-B and CEA. Cytokines corresponded with CRC advancement. FGF2, GM-CSF, IL-1β, IL-6, MIP-1α, PDGF-BB, TNF-α, and VEGF-A were higher than in controls already in stage I CRC with FGF2, IL1-β, and MIP-1α higher than in high CRC-risk individuals as well. Cytokine panels devised to differentiate early CRC from controls, adenomas, or inflammatory bowel disease patients (IBD) had good accuracy but only IBD panel had promising specificity at 95% sensitivity. |
| |
| Keywords: | Colorectal cancer Biomarker Multiplex Cancer screening Cytokines |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
