|
|||||
|
|
TRPM7 mediates breast cancer cell migration and invasion through the MAPK pathway |
|
| Authors: | Xiaojing Meng Chunqing Cai Jiguo Wu Shaoxi Cai Changsheng Ye Haiyang Chen Zhengduo Yang Hongqiang Zeng Qiang Shen Fei Zou |
| Affiliation: | 1. Department of Occupational Health and Occupational Medicine, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, China;2. Department of Respiratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China;3. Breast Center, Nanfang Hospital, Southern Medical University, Guangzhou, China;4. Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA |
| Abstract: | Metastasis is an inherent feature of breast cancer and transient receptor potential (TRP) channels were found to be potentially implicated in this process. Particularly, TRPM7 may regulate cell motility. We therefore examined the expression of TRPM7 mRNA in the Oncomine database and found that TRPM7 is correlated to metastasis and invasive breast cancer. Silencing TRPM7 with RNA interference resulted in a significant decrease in migration and invasion capability of MDA-MB-435 breast cancer cells, and phosphorylation levels of Src and MAPK but not AKT. Our results suggest that TRPM7 regulates migration and invasion of metastatic breast cancer cells via MAPK pathway. |
| Keywords: | TRPM7 Breast cancer Invasion Src MAPK |
| 本文献已被 ScienceDirect 等数据库收录！ | |