High grade prostate intraepithelial neoplasia (PIN) is a PSA-independent risk factor for prostate cancer in African American men: Results from a pilot study |
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| Authors: | Ganna Chornokur Gang Han Richard Tanner Hui-Yi Lin B. Lee Green Julio Pow-Sang Catherine M. Phelan |
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| Affiliation: | 1. Department of Cancer Epidemiology, Moffitt Cancer Center, 12902 Magnolia Dr., Tampa FL33612, USA;2. Department of Biostatistics, Moffitt Cancer Center, 12902 Magnolia Dr., Tampa FL33612, USA;3. Department of Diversity, Moffitt Cancer Center, 12902 Magnolia Dr., Tampa FL33612, USA;4. Department of Genitourinary Oncology, Moffitt Cancer Center, 12902 Magnolia Dr., Tampa FL33612, USA |
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| Abstract: | African American men (AAM) demonstrate increased prostate cancer incidence and mortality rates. We investigated known prostate cancer risk factors in AAM. Prostate specific antigen (PSA) and diagnosis of high grade prostatic intraepithelial neoplasia (PIN) were significant prostate cancer predictors. However, even including AAM with low PSA (<4 ng/ml), those with PIN had significantly elevated risk, compared to men without PIN (83.3% vs. 6.9%, p < 0.0001). In AAM diagnosed with PIN, PSA level was no longer significant (83.3% vs. 92.3%, p = 0.593 respectively). Our results suggest that a history of PIN is highly predictive of prostate cancer in AAM, and help provide PSA-independent venues for screening. |
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| Keywords: | Prostate cancer African American men High grade prostatic intraepithelial neoplasia (PIN) |
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