Human renal cancer stem cells |
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| Authors: | Benedetta Bussolati Benjamin Dekel Bruno Azzarone Giovanni Camussi |
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| Affiliation: | 1. Department of Internal Medicine, Research Center for Experimental Medicine and Molecular Biotechnology Center, University of Torino, Italy;2. The Pediatric Stem Cell Research Institute and Division of Pediatric Nephrology, Edmond and Lily Safra Children’s Hospital, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Israel;3. INSERM UMR, Paul Brousse Hospital, Villejuif, France |
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| Abstract: | Cancer stem cells (CSCs), isolated in renal carcinomas, exhibit tumor-initiating capabilities and pluripotency. No specific CSC markers have been identified so far; therefore, their characterization is mainly based on functional studies. As they are resistant to chemo and radio therapy, renal CSCs may have a relevant role in tumor establishment, progression, and recurrence. CSCs were also shown to contribute to intra-tumor vasculogenesis through an endothelial differentiation and to favor the generation of the pre-metastatic niche through the release of exosomes/microvesicles. |
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| Keywords: | Renal cell carcinoma Wilms&rsquo tumor Tumor stem cells Differentiation therapy Angiogenesis |
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