| 液-质联用测定不同产地独活中蛇床子素和欧前胡素的含量 |
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| 引用本文： | 顿珠次仁,朱根华,邹志琴,严志宏,黄秀珍.液-质联用测定不同产地独活中蛇床子素和欧前胡素的含量[J].中药新药与临床药理,2015,26(1):105-108. |
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| 作者姓名： | 顿珠次仁 朱根华 邹志琴 严志宏 黄秀珍 |
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| 作者单位： | 1. 西藏藏医学院,西藏 拉萨,850000
2. 江西中医药大学,江西 南昌,330004 |
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| 基金项目： | 江西中医药大学校基金---道地药材及特色中药资源研究专项(2012ZR022)。 |
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| 摘 要： | 目的建立不同产地独活中蛇床子素和欧前胡素含量的测定方法。方法采用液相色谱-质谱联用(液-质联用)方法,测定4种不同产地独活中蛇床子素和欧前胡素的含量。液相色谱条件:甲醇-水(体积比,85∶15)作流动相,流速为0.3 m L·min-1,柱温30℃,进样量5μL。质谱条件:电喷雾离子源(ESI),阳离子模式,多反应监测(MRM)方式检测。采用外标法测定蛇床子素和欧前胡素的含量。结果不同产地独活中蛇床子素含量范围为1.11~5.02μg·g-1,欧前胡素的含量范围0.85~9.54μg·g-1。结论不同产地独活中蛇床子素和欧前胡素的含量存在一定的差异。该法可为不同地区独活中药材的质量控制提供参考标准。
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| 关 键 词： | 独活 蛇床子素 欧前胡素 液-质联用 |
| 收稿时间： | 2014/9/24 0:00:00 |
Determination of Osthole and Imperatorin in Radix Angelicae Pubescentis from Different Habitats by HPLC-MS/MS |
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| DUNZHU Ciren,ZHU Genhu,ZOU Zhiqin,YAN Zhihong,HUANG Xiuzhen,DUNZHU Ciren,ZHU Genhu,ZOU Zhiqin,YAN Zhihong,HUANG Xiuzhen,DUNZHU Ciren,ZHU Genhu,ZOU Zhiqin,YAN Zhihong,HUANG Xiuzhen,DUNZHU Ciren,ZHU Genhu,ZOU Zhiqin,YAN Zhihong,HUANG Xiuzhen and DUNZHU Ciren,ZHU Genhu,ZOU Zhiqin,YAN Zhihong,HUANG Xiuzhen.Determination of Osthole and Imperatorin in Radix Angelicae Pubescentis from Different Habitats by HPLC-MS/MS[J].Traditional Chinese Drug Research & Clinical Pharmacology,2015,26(1):105-108. |
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| Authors: | DUNZHU Ciren ZHU Genhu ZOU Zhiqin YAN Zhihong HUANG Xiuzhen DUNZHU Ciren ZHU Genhu ZOU Zhiqin YAN Zhihong HUANG Xiuzhen DUNZHU Ciren ZHU Genhu ZOU Zhiqin YAN Zhihong HUANG Xiuzhen DUNZHU Ciren ZHU Genhu ZOU Zhiqin YAN Zhihong HUANG Xiuzhen and DUNZHU Ciren ZHU Genhu ZOU Zhiqin YAN Zhihong HUANG Xiuzhen |
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| Institution: | DUNZHU Ciren;ZHU Genhua;ZOU Zhiqin;YAN Zhihong;HUANG Xiuzhen;Traditional Tibetan Medicine College;Jiangxi University of Traditional Chinese Medicine; |
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| Abstract: | |
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| Keywords: | Radix Angelicae Pubescentis Osthole Imperatorin High performance liquid chromatography-mass spectrometry/mass spectrometry (HPLC-MS/MS) |
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