Cytokine cross-talk between tubular epithelial cells and interstitial immunocompetent cells |
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Authors: | van Kooten C Daha M R |
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Affiliation: | Department of Nephrology, Leiden University Medical Center, The Netherlands. Kooten@lumc.nl |
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Abstract: | Immunostaining of renal biopsies of patients with interstitial rejection of allografts or other forms of interstitial inflammation has demonstrated the presence of activated T cells and monocytes/macrophages in the tubulointerstitial area. Cytokines that are produced by infiltrating cells are capable of activating tubular epithelial cells. In turn tubular epithelial cells can produce a wide variety of inflammatory mediators, including chemokines, which further regulate cellular influx. Interfering in this cross-talk between tubular epithelial cells and infiltrating cells might provide new options for therapeutic intervention. |
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