High prevalence of human papillomavirus type 58 in Mexican colposcopy patients. |
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Authors: | Maria del Refugio González-Losa Iván Rosado-Lopez Nina Valdez-González Marylín Puerto-Solís |
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Institution: | Virology Laboratory, Regional Research Center, Dr. Hideyo Noguchi, Autonomous University of Yucatán, Avenida Itzaez con Calle 59 No. 490, Col. Centro, Mérida, Yucatan 97000, Mexico. glosa@tunku.uady.mx |
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Abstract: | BACKGROUND: Cervical cancer is the second most common cancer of the women worldwide. Infection with some genotypes of human papillomavirus is the most important risk factor associated to cervical cancer. OBJECTIVE: To determine the prevalence and genotypes of papillomavirus in biopsies of women with squamous intraepithelial lesion and cervical cancer. STUDY DESIGN: Two hundred sequential patients of colposcopy clinic were studied. HPV diagnosis was done by polymerase chain reaction using MY09/MY11 primers, for genotyping line blot hybridization was used. RESULTS: A total of 186 women were beta globin positive; 104 (55.9%) had histology diagnosis of low-grade squamous intraepitelial lesions (LSIL), 67 (36.0%) high-grade squamous intraepitelial lesions (HSIL) and 15 (8.1%) invasive cervical cancer (IC). The prevalence of HPV was 56.4% (104/185); HPV 58 was founded in 28.5% of all positive women, HPV 16 in 25.7%, HPV 18 in 13.3%, HPV 33 in 11.4% and 31 in 8.5%. In all grades of the lesions HPV 58 was the most frequently. CONCLUSIONS: The high prevalence of HPV 58 among Mexican women with HSIL and IC, has important implications in prophylaxis. |
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