纳洛酮治疗蛛网膜下腔出血

目的 :观察纳洛酮治疗蛛网膜下腔出血(SAH )的疗效。方法 :SAH 72例 ,分为 2组。治疗组 4 0例 ,对照组 32例。对照组按病情给予降颅压药、激素、止血药、钙通道拮抗药、降血压药、降血糖药及营养脑神经药等常规治疗 ;治疗组则在此基础上加用纳洛酮 0 .8mg加入氯化钠注射液 10 0mL中iv ,gtt ,bid ,疗程均为 1mo。结果 :经 1个疗程治疗后 ,纳洛酮组基本痊愈率 75 % ,对照组 34% ,2组疗效比较经Ridit分析 ,差异有非常显著意义 (P<0 .0 1)。纳洛酮组脑血管痉挛和脑梗死发生例数为 (2 / 4 0 )和 (1/ 4 0 )与对照组 (8/ 32 )和 (5 / 32 )比较 ,差异有显著意义 (P <0 .0 5 )。结论 :使用纳洛酮治疗蛛网膜下腔出血安全有效

Naloxone in treatment of subarachnoid hemorrhage

AIM: To observe the clinical efficiency of naloxone in the treatment of subarachnoid hemorrhage(SAH). METHODS: Seventy two patients with SAH were divided into naloxone group ( n =40) and control group ( n =32). Beside routine treatment in all patients, the patients in naloxone group were given naloxone 0.8 mg+0.9 % sodium chloride injection 100 mL iv, gtt, bid, for one month. RESULTS: After one course of treatment, the curative rate was 75 % in naloxone group and 34 % in control group. Comparison of effects between naloxone group and control group by Ridit analysis was singnificantly different ( P <0.01). The occurrence of spasm of blood vessel in brain and cerebral infarction was (2/42) and (1/42) in naloxone group, (8/30) and (5/30) in control group. Comparison of complication between naloxone group and control group was different ( P <0.05). CONCLUSION: Naloxone is an effective and safe drug in treatment of SAH.