| 老年起病的类风湿关节炎血清中葡萄糖6磷酸异构酶的临床意义 |
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| 引用本文： | 李博,叶志中,陈雅硕,何伟珍,孔卫红,谢燕,张丽君,李剑松. 老年起病的类风湿关节炎血清中葡萄糖6磷酸异构酶的临床意义[J]. 实用老年医学, 2011, 25(5): 382-383,387. DOI: 10.3969/j.issn.1003-9198.2011.05.009 |
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| 作者姓名： | 李博 叶志中 陈雅硕 何伟珍 孔卫红 谢燕 张丽君 李剑松 |
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| 作者单位： | 深圳市第四人民医院香蜜湖风湿病分院 广东医学院深圳风湿病学研究所,广东省深圳市,518040 |
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| 基金项目： | 深圳市医学重点学科建设基金资助项目 |
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| 摘 要： | 目的探讨葡萄糖6磷酸异构酶（GPI）在老年起病的类风湿关节炎（EORA）患者血清中的临床意义,探讨其与EORA病情活动性之间的相关性。方法对36例EORA患者及48例健康老年人的血清进行了GPI的测定,并在EORA患者中对GPI与病情活动性之间的关系进行了分析。结果 36例EORA患者中,GPI阳性率为75%（27/36）。48例健康老年人中,仅有5例检测到GPI,GPI阳性率为10.4%（5/48）。GPI在EORA患者中的敏感性及特异性分别为75%及82.7%。以28处关节疾病活动度积分（DAS28）来评价EORA患者的病情活动性,在EORA患者中,GPI阳性组患者的病情活动性显著高于GPI阴性组患者（P〈0.05）。结论 GPI有助于EORA的诊断及病情活动性判断。
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| 关 键 词： | 葡萄糖6磷酸异构酶 老年起病的类风湿关节炎 病情活动性 |
Clinical significance of glucose-6-phosphate isomerase in patients with elderly-onset rheumatoid arthritis |
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| LI Bo,YE Zhi-zhong,CHEN Ya-shuo,HE Wei-zhen,KONG Wei-hong,XIE Yan,ZHANG Li-jun,LI Jian-song. Clinical significance of glucose-6-phosphate isomerase in patients with elderly-onset rheumatoid arthritis[J]. Practical Geriatrics, 2011, 25(5): 382-383,387. DOI: 10.3969/j.issn.1003-9198.2011.05.009 |
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| Authors: | LI Bo YE Zhi-zhong CHEN Ya-shuo HE Wei-zhen KONG Wei-hong XIE Yan ZHANG Li-jun LI Jian-song |
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| Affiliation: | LI Bo,YE Zhi-zhong,CHEN Ya-shuo,HE Wei-zhen,KONG Wei-hong,XIE Yan,ZHANG Li-jun,LI Jian-song.Department of Rheumatology,Xiangmihu Branch of Shenzhen Fourth People's Hospital,Shenzhen 518040,China |
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| Abstract: | Objective To explore the clinical significance of glucose-6-phosphate isomerase(GPI) in patients with elderly-onset rheumatoid arthritis(EORA).Methods Serum samples obtained from 36 patients with EORA,82 patients with none-elderly onset rheumatoid arthritis(NEORA) and 48 healthy controls were assayed for glucose-6-phosphate isomerase(by ELISA),and the relationship between GPI and the disease activity in EORA patients was analyzed.Results The prevalence of GPI was 75%,45% and 10% in EORA patients,NEORA patie... |
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| Keywords: | glucose-6-phosphate isomerase elderly-onset rheumatoid arthritis disease activity |
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