| 液质联用测定人血浆中泮托拉唑的浓度 |
| |
| 引用本文： | 刘朋,黄建权,陈頔,孙春华.液质联用测定人血浆中泮托拉唑的浓度[J].中国药学杂志,2013,48(8):633-635. |
| |
| 作者姓名： | 刘朋 黄建权 陈頔 孙春华 |
| |
| 作者单位： | 1.卫生部北京医院药学部， 北京 100730； 2. 航天中心医院药剂科， 北京 100049) |
| |
| 摘 要： | 目的 测定人血浆中泮托拉唑的浓度，并评价国产和进口泮托拉唑钠肠溶片的生物等效性。方法 采用LC-MS/MS测定人血浆中泮托拉唑的浓度，以DAS2.0计算药动学参数考察其生物等效性。结果 受试制剂和参比制剂的泮托拉唑t1/2分别为（1.96±0.66）和（1.98±0.59）h，tmax分别为（3.17±0.84）和（3.09±0.81）h，ρmax分别为（3.53±0.78）和（3.41±0.79）μg·mL-1，AUC0-∞分别为（10.12±4.09）和（10.86±3.99）μg·h·mL-1。生物利用度为（97.9±22.3）%。结论 该方法重复性好，灵敏度高，泮托拉唑钠肠溶片受试制剂和参比制剂具有生物等效性。
|
| 关 键 词： | 高效液相质谱联用 泮托拉唑 生物等效性 |
| 收稿时间： | 2012-04-02; |
Determination of Pantoprazole in Human Plasma by LC-MS/MS |
| |
| LIU Peng,HUANG Jian-quan,CHEN Di,SUN Chun-hua.Determination of Pantoprazole in Human Plasma by LC-MS/MS[J].Chinese Pharmaceutical Journal,2013,48(8):633-635. |
| |
| Authors: | LIU Peng HUANG Jian-quan CHEN Di SUN Chun-hua |
| |
| Institution: | 1.Department of Pharmacy, Beijing Hospital, the Ministry of Health, Beijing 100730, China; 2.Department of Pharmacy, Aerospace Central Hospital, Beijing 100049, China |
| |
| Abstract: | OBJECTIVE To determine the concentration of pantoprazole in human plasma and evaluate the bioequivalence of two kinds of pantoprazole sodium enteric-coated tablets. METHODS The concentration of pantoprazole in human plasma was determined by LC-MS/MS， and the pharmacokinetic parameters for evaluation of bioequivalence were calculated with DAS2.0. RESULTS The main pharmacokinetic parameters of test and reference formulation were as followst1/2 (1.96±0.66) and (1.98±0.59) h， (3.17±0.84) and (3.09±0.81) h， ρmax (3.53±0.78) and (3.41±0.79) μg·mL-1， AUC0-∞ (10.12±4.09) and (10.86±3.99) μg·h·mL-1. The relative bioavailability was （97.9±22.3）%. CONCLUSION The method is repeatable and sensitive. The test and reference formulation are bioequivalent. |
| |
| Keywords: | LC-MS/MS pantoprazole bioequivalence |
|
| 点击此处可从《中国药学杂志》浏览原始摘要信息 |
| 点击此处可从《中国药学杂志》下载免费的PDF全文 |
