新型肿瘤标志物细胞角蛋白19片段2G2诊断肺癌的临床价值 |
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引用本文: | 张宏艳,梁峰,刘畅,贾志凌. 新型肿瘤标志物细胞角蛋白19片段2G2诊断肺癌的临床价值[J]. 肿瘤研究与临床, 2013, 25(3): 145-147 |
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作者姓名: | 张宏艳 梁峰 刘畅 贾志凌 |
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作者单位: | 1. 北京军区总医院肿瘤科2. 北京,军事医学科学院附属医院普外科3. 北京军区总医院检验科 |
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摘 要: | 目的 探讨新型肿瘤标志物细胞角蛋白19片段2G2(CK19-2G2)血清水平对肺癌的诊断价值。方法 采用化学发光法检测并比较了150例肺癌、50例肺炎和150名健康体检者空腹血清中CK19-2G2水平,对比血清CK19-2G2与CYFRA21-1水平对肺癌的诊断效能。结果 CK19-2G2诊断肺癌的敏感度和准确度分别为55.3 %(83/150)、80.3 %(281/350),而CYFRA21-1诊断肺癌的敏感度和准确度分别为28.0 %(42/150)、67.4 %(236/350)。CK19-2G2敏感度和准确度高于CYFRA21-1(P<0.001)。结论 新型肿瘤标志物CK19-2G2血清水平能够起到肺癌临床辅助诊断的作用。
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关 键 词: | 肺肿瘤 角蛋白19 CYFRA21-1 |
Diagnostic value of a new tumor marker CK19-2G2 for lung cancer |
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Abstract: | Objective To investigate the diagnostic value of a new tumor marker CK19-2G2 for lung cancer. Methods The serum levels of CK19-2G2 in 150 lung cancer patients, 50 pulmonitis patients and 50 healthy controls were detected with chemoluminescence. The diagnostic efficacy between the serum levels of CK19-2G2 and CYFRA21-1 were compared. Results The sensitivity and accuracy of CK19-2G2 were 55.3 % (83/150) and 80.3 % (281/350), respectively, while the sensitivity and accuracy of CYFRA21-1 were 28.0 % (42/150) and 67.4 % (236/350), respectively. The differences were significant (P < 0.001). Conclusion The detection of CK19-2G2 may be a new diagnostic tumor marker for lung cancer. |
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Keywords: | Lung neoplasms Karatin-19 CYFRA21-1 |
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