脐带血乙肝标志物筛查乙肝病毒宫内感染的探讨

目的探讨脐带血乙肝标志物用于筛查乙肝病毒宫内感染的可能性。方法收集175例HBsAg阳性孕妇新生儿脐带血及24 h外周血,进行乙肝标志物和HBV DNA检测,6月龄时随访查外周血HBsAg。结果脐带血HBsAg阳性的新生儿外周血HBV DNA均为阳性,6月龄随访HBsAg阳性率均为100%。7例出生时注射了HBIG和乙肝疫苗的HBV DNA阳性的新生儿HBsAg随访阴转;8例脐带血HBsAg和HBV DNA均阴性的婴儿因直接母乳喂养HBsAg随访阳转。结论脐带血表面抗原可以作为筛查胎儿乙肝病毒宫内感染的指标。

Screening of intrauterine infection with HBV using hepatitis B virus marks

Objective To explore possibility screening of intrauterine infection with HBV using hepatitis B virus marks in umbilical cord blood. Methods 175 cases umbilical cord blood of the pregnant woman with positive HBsAg and the newborn＇s neonace in 24 hours age were collected. Epatitis B virus marks of the umbilical cord blood and HBV DNA of the neonate were detected. The HBsAg of the infant in 6 months age was followed up. Results The HBV DNA of the newborn＇s neonace with positive HBsAg in umbilical cord blood was detected to be positive, and the HBsAg rate followed up in 6 mouths age was 100%. 7 cases newborn positive in HBV DNA injected with HBIG and epatitis B vaccine were de tected negative HBsAg in 6 months. 8 cases infant with negative HBsAg in umbilical cord blood and HBV DNA in neo nace were catched HBV in breast feeding. Conclusion The HBsAg of umbilical cord blood might been regarded as the screening way of HBV intrauterine infection.