| 25例乙肝患者HBV基因分型 |
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| 引用本文： | 李伟,江其生,宋秀军,陈舒. 25例乙肝患者HBV基因分型[J]. 中国寄生虫病防治杂志, 2009, 0(8): 636-636 |
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| 作者姓名： | 李伟 江其生 宋秀军 陈舒 |
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| 作者单位： | 第二炮兵总医院中心实验室,北京100088 |
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| 摘 要： | 对随机挑选的25例荧光定量PCR检测HBV-DNA阳性的乙肝患者,进行乙肝病毒（HBV）基因分型,并分析其与乙肝血清标记物及谷丙转氨酶之间的关系。结果检出HBV B型5例,占20.00%;C型16例,占64.00%;非B非C型4例,占16.00%。B型HBeAg阳性率为40.00%,C型HBeAg阳性率93.75%,B、C型谷丙转氨酶阳性率分别为20.00%和37.50%。结果表明,乙肝病人HBV感染以C型为主,且C型感染者HBeAg阳性率比B型感染者高。C型HBV可能与HBV复制有相关性。
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| 关 键 词： | 乙肝病毒 基因分型 HBV-DNA |
HBV genotype in 25 cases of patients with the hepatitis B virus |
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| Affiliation: | LI Wei, JIANG Qi-sheng, SONG Xiu-jun, et al (Central Laboratory, General Hospital of The Second Artil lery, Beijing 100088, China) |
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| Abstract: | Twenty-five HBV-DNA positive samples were randomly selected and used in hepatitis B virus （HBV） genotyping, and then the relationship between HBV serum biomarkers and ALT was studied. The results indicated that five samples were genotype B （20.00% ）, sixteen were genotype C （64.00% ）, and four samples were neither genotype B nor C （16.00%）. With genotype B, HBeAg was positive in 40.00% of samples, and with genotype C HBeAg was positive in 93.75% of samples. With genotypes B and C, ALT was positive in 20.00% and 37. 50% of cases, respectively. These results indicated that patients infected with HBV were mainly genotype C （93.75 %）, and more individuals infected with genotype C were positive for HBeAg than those infected with genotype B. HBV genotype C may be associated with HBV replication. |
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| Keywords: | HBV genotype HBV-DNA |
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