男性血清抵抗素、脂联素水平与骨密度的关系：232名资料分析

目的：调查分析长沙地区232名健康男性志愿者血清抵抗素、脂联素水平与骨密度的关系。 方法：随机选择长沙地区汉族健康男性志愿者232名，对调查方案均知情同意，排除患有影响骨代谢疾病、服用影响骨代谢药物者。用酶联免疫吸附试验测定受试者血清脂联素、抵抗素水平；用DXA测定总体、腰椎正位、总髋部骨密度，全身扫描测定体脂水平及瘦体质量。分析血清脂联素、抵抗素水平与体脂及各部位骨密度的关系；利用逐步多元线性回归分析各部位骨密度的影响因素。结果：抵抗素与体脂无相关性。脂联素与体脂呈负相关(r= -0.216，P < 0.05)，校正年龄与体质量指数后，相关性消失(r= -0.006，P > 0.05)。脂联素与总体、腰椎正位、总髋部骨密度呈负相关，校正年龄与体脂后，相关性存在。抵抗素与总体、腰椎正位、总髋部骨密度无相关性。多元线性回归分析显示脂联素是男性各部位骨密度的独立影响因素。 结论：抵抗素与体脂及各部位骨密度均无相关性。脂联素与体脂相关，与各部位骨密度呈负相关，是男性各部位骨密度的独立影响因素。

Relationships between serum resistin, adiponectin levels and bone mineral density in Chinese men: Data analysis of 232 volunteers

OBJECTIVE: To investigate the correlation of serum resistin and adiponectin levels with bone mineral density (BMD) in 232 healthy male volunteers in Changsha area. METHODS: A total of 232 healthy Chinese men of Han population were selected randomly from Changsha area. All subjects gave their informed consent to participate in this study. Subjects were excluded from the study if they had conditions or received treatment that affecting bone metabolism. Serum adiponectin and resistin levels were determined by ELISA. BMD was measured by dual energy X-ray absorptiometry in total body, lumbar spine, and total hip. Body fat mass and lean body mass were measured by the whole body scanning. The correlation of serum adiponectin and resistin levels with fat mass and BMD at various sites were analyzed; the predictors of BMD at various sites was assayed using multiple linear stepwise regression analysis.RESULTS: Adiponectin was negatively correlated with fat mass (r=-0.216, P < 0.05), while resistin had no correlation with fat mass. The correlation disappeared after adjustment for age and fat mass (r=-0.006, P > 0.05). The significant negative correlations between adiponectin and BMD were found, and remained significant after adjustment for age and fat mass. There was no correlation between resistin and BMD at various sites. In the multiple linear stepwise regression analysis, adiponectin was an independent predictor of BMD in men. CONCLUSION: Resistin is not correlated with fat mass and BMD at various sites. Adiponectin is correlated with fat mass, and has a negative correlation with BMD at various sites, it is an independent predictor of BMD in Chinese men.