Passive accumulation of magnesium,sodium, and potassium by chick calvaria |
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Authors: | Robert Brommage William F Neuman |
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Institution: | (1) Department of Radiation Biology and Biophysics, University of Rochester School of Medicine and Dentistry, 14642 Rochester, New York, USA;(2) Present address: Pathophysiologisches Institut, Universitat Bern Murtenstrasse 35, CH3008 Bern, Switzerland |
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Abstract: | Summary Four-day-old chick calvaria were used to determine the passive concentrations of magnesium, sodium, and potassium in metabolically
poisoned bone. When incubated in buffers containing the blood levels of sodium and magnesium, these calvaria contained sodium
and magnesium at the identical concentrations found in freshly dissected calvaria. Calvarial sodium and magnesium levels could
be varied by altering the buffer concentrations of these cations. The potassium content of metabolically poisoned calvaria
incubated in buffers containing 4 mM potassium was less than 20% of the content of freshly dissected calvaria. When the buffer
concentrations of sodium and potassium were systematically varied, ouabain-poisoned calvaria concentrated these cations in
the bone extracellular fluid by a factor of approximately two above buffer cation levels. Presumably, the hydroxyapatite crystal
zeta potential is responsible for this concentrative phenomenon. These results are discussed in terms of the control of the
ionic content of the bone extracellular fluid by the postulated “bone membrane.” |
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Keywords: | Bone membrane Zeta potential Bone potassium Calvaria Bone extracellular fluid |
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